Document Detail

Severe pre-eclampsia and infants of very low birth weight.
MedLine Citation:
PMID:  3632019     Owner:  NLM     Status:  MEDLINE    
The effect of severe pre-eclampsia on the outcome of infants of very low birth weight was studied in a prospective case control study of 35 pairs of infants of comparable gestation. Significantly more infants were delivered before the onset of labour and by caesarean section in the group with pre-eclampsia. These babies tended to be smaller and had a higher incidence of hyaline membrane disease, patent ductus arteriosus, pulmonary air leak, and hypotension. They also required more intensive treatment with oxygen and mechanical ventilation. The significant difference in birth weight was still apparent at 2 years of age. Although the mean psychomotor developmental index and the incidence of specific neurodevelopmental impairments were not significantly different between the two groups, survivors in the group born to pre-eclamptic mothers had a significantly lower mean mental developmental index, and significantly more of these children had one or more impairments compared with the control group at 2 years of age.
W Szymonowicz; V Y Yu
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Archives of disease in childhood     Volume:  62     ISSN:  1468-2044     ISO Abbreviation:  Arch. Dis. Child.     Publication Date:  1987 Jul 
Date Detail:
Created Date:  1987-10-21     Completed Date:  1987-10-21     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0372434     Medline TA:  Arch Dis Child     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  712-6     Citation Subset:  AIM; IM    
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MeSH Terms
Birth Weight
Child Development
Infant, Low Birth Weight*
Infant, Newborn
Infant, Premature, Diseases / etiology*
Maternal-Fetal Exchange
Pre-Eclampsia / complications*,  drug therapy
Prospective Studies

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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