Document Detail

Severe postnatal cytomegalovirus infection in a very premature infant.
MedLine Citation:
PMID:  17570943     Owner:  NLM     Status:  MEDLINE    
Several studies have reported that postnatally acquired cytomegalovirus (CMV) infection can cause sepsis-like syndrome in premature infants. We here report a 622-gram birth weight male infant of 23 weeks' gestation who had sepsis-like syndrome and pneumonia. Substantial CMV loads were detected in peripheral blood cells, plasma, and urine when the patient was in crisis, but was decreased in parallel to clinical improvement without using ganciclovir. CMV DNA was not detected from his umbilical cord or Guthrie card, even by highly sensitive real-time PCR. Molecular profiles were indistinguishable between the CMV strain isolated from his urine and that from maternal breast milk, indicating postnatal acquisition of CMV through breast milk. Although he had transient hearing impairment, his neurodevelopmental outcome of 30 months of corrected age was normal. Further accumulation of clinical and virological data in postnatal CMV infection is necessary for evaluating the severity and selecting patients requiring antiviral therapy.
Ritsuko Takahashi; Masato Tagawa; Masatoshi Sanjo; Hiroo Chiba; Takeshi Ito; Masaaki Yamada; Shingi Nakae; Akira Suzuki; Hidekazu Nishimura; Masako Naganuma; Norio Tominaga; Masako Moriuchi; Hiroyuki Moriuchi
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2007-06-15
Journal Detail:
Title:  Neonatology     Volume:  92     ISSN:  1661-7819     ISO Abbreviation:  -     Publication Date:  2007  
Date Detail:
Created Date:  2007-11-16     Completed Date:  2007-12-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101286577     Medline TA:  Neonatology     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  236-9     Citation Subset:  IM    
Copyright Information:
(c) 2007 S. Karger AG, Basel.
Neonatal Intensive Care Unit in Perinatal Center, Japanese Red Cross Sendai Hospital, Sendai, Japan.
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MeSH Terms
Antiviral Agents / therapeutic use
Cytomegalovirus / isolation & purification,  pathogenicity
Cytomegalovirus Infections / diagnosis*,  drug therapy,  transmission*
Ganciclovir / therapeutic use
Infant, Newborn
Infant, Premature*
Milk, Human / virology*
Severity of Illness Index
Reg. No./Substance:
0/Antiviral Agents; 82410-32-0/Ganciclovir

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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