Document Detail

Severe pneumonia with pneumatoceles and patent foramen ovale in an infant: optimal ventilation strategy?
MedLine Citation:
PMID:  16930105     Owner:  NLM     Status:  MEDLINE    
We discuss a case of severe pneumonia with pneumatoceles in a 2-month old infant. Despite peak and plateau airway pressures kept below 30 and 25 cmH(2)O, respectively, the infant developed bilateral pneumothorax and pneumomediastinum caused by pneumatocele rupture, necessitating bilateral intercostal drainage. Application of positive end-expiratory pressure (PEEP) of 10 cmH(2)O at FIO(2) of 0.7 worsened oxygenation, and transthoracic echocardiography showed right-to-left shunting of blood through the patent foramen ovale. Therefore, PEEP had to be tapered to 6 cmH(2)O, and ventilation carried out at FIO(2) of 1 until the lung condition improved. The open lung strategy of higher increments of PEEP and lower FIO(2) for lung protective ventilation actually proved deleterious to our patient. We conclude that a subset of patients with acute respiratory distress syndrome with refractory hypoxaemia may have right-to-left shunting of blood through a patent foramen ovale. This can be detected by echocardiography, and these patients may benefit from a ventilation strategy aimed at lowering pulmonary vascular resistance.
Nevin K Chinnan; Ashraf Im Shabaan; Muhammad Saeed; Wael A Samman
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine     Volume:  8     ISSN:  1441-2772     ISO Abbreviation:  Crit Care Resusc     Publication Date:  2006 Sep 
Date Detail:
Created Date:  2006-08-25     Completed Date:  2006-10-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100888170     Medline TA:  Crit Care Resusc     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  209-12     Citation Subset:  IM    
Department of Anaesthesia and Intensive Care Unit, King Khalid Hospital, Najran, Saudi Arabia.
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MeSH Terms
Heart Septal Defects, Atrial / complications*,  ultrasonography
Pneumonia / complications,  therapy*
Positive-Pressure Respiration / methods*
Respiratory Distress Syndrome, Adult / complications,  therapy*
Vascular Resistance

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