Document Detail

Severe physical exertion, oxidative stress, and acute lung injury.
MedLine Citation:
PMID:  22064719     Owner:  NLM     Status:  In-Data-Review    
ABSTRACT: We report the case of a 27-year-old male athlete presenting with severe dyspnoea 24 hours after completing an \x{201c}Ironman Triathlon.\x{201d} Subsequent chest radiology excluded pulmonary embolus but confirmed an acute lung injury (ALI). Echocardiography corroborated a normal brain natriuretic peptide level by demonstrating good biventricular systolic function with no regional wall motion abnormalities. He recovered well, without requiring ventilatory support, on supplemental oxygen therapy and empirical antibiotics. To date, ALI following severe physical exertion has never been described. Exercise is a form of physiological stress resulting in oxidative stress through generation of reactive oxygen/nitrogen species. In its extreme form, there is potential for an excessive oxidative stress response\x{2013}one that overwhelms the body's protective antioxidant mechanisms. As our case demonstrated, oxidative stress secondary to severe physical exertion was the most likely factor in the pathogenesis of ALI. Further studies are necessary to explore the pathological consequences of exercise-induced oxidative stress. Although unproven as of yet, further research may be needed to demonstrate if antioxidant therapy can prevent or ameliorate potential life-threatening complications in the acute setting.
Nikunj R Shah; M Bilal Iqbal; Andrew Barlow; John Bayliss
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical journal of sport medicine : official journal of the Canadian Academy of Sport Medicine     Volume:  21     ISSN:  1536-3724     ISO Abbreviation:  Clin J Sport Med     Publication Date:  2011 Nov 
Date Detail:
Created Date:  2011-11-08     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9103300     Medline TA:  Clin J Sport Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  537-8     Citation Subset:  IM    
Departments of *Cardiology †Respiratory Medicine, Watford General Hospital, Hertfordshire, United Kingdom.
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