Document Detail


Severe phenylephrine-associated hemorrhage in five aged horses.
MedLine Citation:
PMID:  20919849     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
CASE DESCRIPTION: 5 aged (≥ 17 years old) horses developed life-threatening Internal hemorrhage following IV administration of phenylephrine at 3 hospitals. CLINICAL FINDINGS: All 5 horses developed severe hemothorax, hemoabdomen, or both within minutes to hours following administration of phenylephrine. TREATMENT AND OUTCOME: Four of 5 horses died of hemorrhagic shock, and 1 horse survived with a blood transfusion. The exact source of hemorrhage was Identified In only 1 horse. Medical records of all horses with nephrosplenic entrapment of the large colon and treated with phenylephrine at the University of Florida Veterinary Medical Center between 2000 and 2008 (n = 74) were reviewed. Three of these 74 (4%) horses developed fatal hemorrhage (horses 1 through 3 of this report). The risk of developing phenylephrine-associated hemorrhage was 64 times as high (95% confidence interval, 3.7 to 1,116) in horses ≥ 15 years old than in horses < 15 years old. CLINICAL RELEVANCE: The potential risks versus benefits of phenylephrine administration should be evaluated carefully, especially In old horses.
Authors:
Jeremy Frederick; Steeve Giguère; Kelly Butterworth; Alessandra Pellegrini-Masini; Raul Casas-Dolz; Meg Miller Turpin
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of the American Veterinary Medical Association     Volume:  237     ISSN:  0003-1488     ISO Abbreviation:  J. Am. Vet. Med. Assoc.     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-10-05     Completed Date:  2010-11-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7503067     Medline TA:  J Am Vet Med Assoc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  830-4     Citation Subset:  IM    
Affiliation:
Department of Large Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL 32610, USA.
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MeSH Terms
Descriptor/Qualifier:
Adrenergic alpha-Agonists / adverse effects*
Aging*
Animals
Fatal Outcome
Hemorrhage / chemically induced,  veterinary*
Horse Diseases / chemically induced*
Horses
Phenylephrine / adverse effects*
Chemical
Reg. No./Substance:
0/Adrenergic alpha-Agonists; 59-42-7/Phenylephrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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