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Severe pertussis in infants: estimated impact of first vaccine dose at 6 versus 8 weeks in australia.
MedLine Citation:
PMID:  20811313     Owner:  NLM     Status:  In-Data-Review    
We estimated the potential benefits of advancing the first dose of pertussis vaccine for infants from 8 to 6 weeks of age, using Australian national disease databases. Infants had notification rates 3-fold greater than the general population and accounted for 52% of recorded hospitalizations. Infants 1 and 2 months of age had notification rates 3.5 times (95% CI: 2.7-4.5) higher than infants 3 to 11 months of age. Estimation of acceleration of the vaccine to 6 weeks of age reduced average notifications, hospitalizations, and hospital bed-days by 8%, 9%, and 12%, respectively, with larger reductions in an epidemic year.
Alice Ruth Foxwell; Peter McIntyre; Helen Quinn; Katrina Roper; Mark S Clements
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Pediatric infectious disease journal     Volume:  30     ISSN:  1532-0987     ISO Abbreviation:  Pediatr. Infect. Dis. J.     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-01-18     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8701858     Medline TA:  Pediatr Infect Dis J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  161-3     Citation Subset:  IM    
From the *Communicable Disease and Surveillance Branch, Office of Health Protection, Department of Health and Ageing, Australian Government, Canberra, Australia; †National Centre for Epidemiology and Population Health, Australian National University, Canberra, Australia; and ‡National Centre for Immunisation Research and Surveillance of Vaccine Preventable Diseases, The Children's Hospital at Westmead and the University of Sydney, Sydney, Australia.
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