| Severe paroxysmal hypertension (pseudopheochromocytoma). | |
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MedLine Citation:
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PMID: 18367021 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Paroxysmal hypertension always engenders a search for a catecholamine-secreting pheochromocytoma. Yet 98% of people with paroxysmal hypertension do not have this tumor. The cause and management of paroxysmal hypertension remain a mystery, and the subject of remarkably few papers. This review presents an approach to understanding and successfully treating this disorder. Patients experience symptomatic blood pressure surges likely linked to sympathetic nervous system stimulation. A specific personality profile associated with this disorder suggests a psychological basis, attributable to repressed emotion related to prior emotional trauma or a repressive (nonemotional) coping style. Based on this understanding, three forms of intervention, alone or in combination, appear successful: antihypertensive therapy with agents directed at the sympathetically mediated blood pressure elevation (eg, combined alpha- and beta-blockade or central alpha-agonists such as clonidine); psychopharmacologic interventions including anxiolytic and/or antidepressant agents; and psychological intervention, particularly reassurance and increased psychological awareness. An appropriately selected intervention can reduce or eliminate attacks in most patients. |
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Authors:
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Samuel J Mann |
Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Current hypertension reports Volume: 10 ISSN: 1534-3111 ISO Abbreviation: Curr. Hypertens. Rep. Publication Date: 2008 Feb |
Date Detail:
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Created Date: 2008-03-27 Completed Date: 2008-05-06 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100888982 Medline TA: Curr Hypertens Rep Country: United States |
Other Details:
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Languages: eng Pagination: 12-8 Citation Subset: IM |
Affiliation:
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New York Presbyterian Hospital-Weill/Cornell Medical School, 450 East 69th Street, New York, NY 10021, USA. sjmann@med.cornell.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenal Gland Neoplasms
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complications,
diagnosis Anti-Anxiety Agents / therapeutic use Antidepressive Agents / therapeutic use Antihypertensive Agents / therapeutic use Blood Pressure Monitoring, Ambulatory Diagnosis, Differential Emotions* Humans Hypertension / drug therapy*, physiopathology, psychology*, therapy Panic Disorder / complications Pheochromocytoma / complications, diagnosis Psychotherapy Stress Disorders, Post-Traumatic / complications, diagnosis* Sympathetic Nervous System / physiopathology |
| Chemical | |
Reg. No./Substance:
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0/Anti-Anxiety Agents; 0/Antidepressive Agents; 0/Antihypertensive Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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