Document Detail

Severe osteomalacia due to undiagnosed coeliac disease: three case reports of Tunisian women.
MedLine Citation:
PMID:  15977009     Owner:  NLM     Status:  MEDLINE    
We describe three cases of osteomalacia presenting in Tunisian women, all of whom had previously-undiagnosed coeliac disease (CD). Direct enquiry revealed an important weight loss and a history of diarrhoea in two patients, and a 15-year history of anaemia in one patient. Laboratory tests showed severe anaemia in the three cases. Reduced calcium was found in two cases, and corrected calcium was found in one case. Radiological examination showed fissure in two cases. The diagnosis of osteomalacia was made by clinical, biochemical and radiological features. Antigliadin, antireticulin, antiendomysial and anti-tissue transglutaminase antibodies were all positive in the three cases, and a small-bowel biopsy confirmed the diagnosis of CD. Treatment with gluten-free diet (GFD), supplemental calcium and vitamin D was initiated for the three patients, but only one patient complies strictly with the GFD; she showed a marked resolution of her symptoms.
Hanène Landolsi; Elyès Bouajina; Amani Mankaï; Hela Zeglaoui; Karim Skandrani; Ibtissem Ghedira
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2005-06-24
Journal Detail:
Title:  Rheumatology international     Volume:  26     ISSN:  0172-8172     ISO Abbreviation:  Rheumatol. Int.     Publication Date:  2006 Jan 
Date Detail:
Created Date:  2005-12-20     Completed Date:  2006-10-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8206885     Medline TA:  Rheumatol Int     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  261-3     Citation Subset:  IM    
Laboratory of Immunology, Farhat Hached Hospital, Rue Ibn El Jazzar, 4000, Sousse, Tunisia.
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MeSH Terms
Autoantibodies / blood
Calcium / blood
Celiac Disease / complications*,  diagnosis
Middle Aged
Osteomalacia / blood,  etiology*
Vitamin D / blood
Reg. No./Substance:
0/Autoantibodies; 1406-16-2/Vitamin D; 7440-70-2/Calcium

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