Document Detail

Severe obesity associated with cardiovascular deconditioning, high prevalence of cardiovascular risk factors, diabetes mellitus/hyperinsulinemia, and respiratory compromise.
MedLine Citation:
PMID:  15192624     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To determine the extent and severity of obesity-related cardiorespiratory morbidity in children with body mass index (BMI) >or=40 kg/m(2). STUDY DESIGN: Cross-sectional analysis of a cohort comprised of 48 boys and girls aged 8 to 17 years with BMI >or=40 kg/m(2). Cardiorespiratory fitness (graded cycle exercise test), left ventricular (LV) mass (echocardiography), blood pressure, fasting lipid profile, fasting insulin, fasting glucose, HbA1c, and pulmonary function (spirometry and sleep studies) were measured. RESULTS: The cohort averaged 14.2 +/- 2 years of age with mean BMI of 45.5 kg/m(2). Only 2 patients had normal fitness; 37 of 48 had peak oxygen consumption <20 mL O(2)/minute. Hypertension was present in 10 of 48 patients. Mean lipid values were: triglycerides 103 +/- 48 mg/dL, HDL cholesterol 41 +/- 10 mg/dL, and LDL cholesterol 108 +/- 26 mg/dL. Type II diabetes mellitus was diagnosed in 6 patients. Mean fasting insulin was 31 +/- 19 microU/mL. Asthma treatment, small airways disease by pulmonary function testing, or both were present in 35 of 48 patients; upper airway obstruction was present in 7 patients. LV hypertrophy was present in 8 patients, with a mean LV mass of 43 +/- 11 g/m(2.7). CONCLUSIONS: Children and adolescents with BMI >or=40 kg/m(2) have substantial cardiorespiratory morbidity including severe physical deconditioning.
Samuel S Gidding; Rodrigo Nehgme; Charles Heise; Carol Muscar; Annie Linton; Sandra Hassink
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of pediatrics     Volume:  144     ISSN:  0022-3476     ISO Abbreviation:  J. Pediatr.     Publication Date:  2004 Jun 
Date Detail:
Created Date:  2004-06-11     Completed Date:  2004-07-15     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0375410     Medline TA:  J Pediatr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  766-9     Citation Subset:  AIM; IM    
Nemours Cardiac Center and the A. I. duPont Hospital for Children, Wilmington, Delaware 19899, USA.
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MeSH Terms
Cardiovascular Deconditioning*
Cardiovascular Diseases / epidemiology*,  prevention & control
Cross-Sectional Studies
Exercise Test
Metabolic Diseases / epidemiology*,  prevention & control
Obesity, Morbid / epidemiology*,  physiopathology
Respiratory Tract Diseases / epidemiology*,  prevention & control
Risk Factors
United States / epidemiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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