Document Detail

Severe nutritional restriction in pregnant rats aggravates hypertension, altered vascular reactivity, and renal development in spontaneously hypertensive rats offspring.
MedLine Citation:
PMID:  11862116     Owner:  NLM     Status:  MEDLINE    
Epidemiologic studies suggest that intrauterine undernutrition plays an important role in the development of arterial hypertension in adulthood. The aim of the current study was to evaluate whether severe nutritional restriction during pregnancy can aggravate hypertension, vascular reactivity changes, and renal development in spontaneously hypertensive rat (SHR) offspring. To investigate the potential existence of gender differences, both male and female offspring of pregnant SHRs on a restricted diet were studied in adulthood. Female pregnant SHRs were fed either normal or 50% of the normal intake diets, during the whole gestational period. Arterial blood pressure and nephron number were determined. Norepinephrine, acetylcholine, and sodium nitroprusside responses in isolated aortic rings from the offspring (male and female, when they reached adulthood) were also evaluated. In the SHR offspring (male and female) the intrauterine undernutrition further increased the blood pressure levels, increased the response to norepinephrine, and decreased the response to acetylcholine, without altering the response to sodium nitroprusside. In addition, it induced a decrease in the number of nephrons in the kidney from adult offspring. In conclusion, fetal undernutrition aggravates hypertension and the endothelial dysfunction along with an impairment of renal development in both male and female SHRs.
Maria do Carmo P Franco; Robéria Maria M P Arruda; Zuleica B Fortes; Sérgio Ferreira de Oliveira; Maria Helena C Carvalho; Rita C A Tostes; Dorothy Nigro
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of cardiovascular pharmacology     Volume:  39     ISSN:  0160-2446     ISO Abbreviation:  J. Cardiovasc. Pharmacol.     Publication Date:  2002 Mar 
Date Detail:
Created Date:  2002-02-25     Completed Date:  2002-08-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7902492     Medline TA:  J Cardiovasc Pharmacol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  369-77     Citation Subset:  IM    
Laboratory of Hypertension, Department of Pharmacology, Institute of Biomedical Science, University of São Paulo, São Paulo, SP, Brazil.
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MeSH Terms
Aging / physiology
Animals, Newborn
Aorta, Thoracic / physiopathology
Birth Weight
Blood Glucose / analysis
Blood Pressure
Body Weight
Endothelium, Vascular / physiopathology
Food Deprivation
Hypertension / physiopathology*
Kidney* / embryology,  growth & development
Nephrons / embryology,  growth & development
Prenatal Exposure Delayed Effects*
Rats, Inbred SHR
Sex Factors
Vasomotor System / physiopathology*
Reg. No./Substance:
0/Blood Glucose

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