Document Detail

Severe neonatal hyperbilirubinemia. A potential complication of glucose-6-phosphate dehydrogenase deficiency.
MedLine Citation:
PMID:  9779335     Owner:  NLM     Status:  MEDLINE    
G-6-PD deficiency is frequently associated with neonatal hyperbilirubinemia, which may be severe enough to cause kernicterus and death. Because of its association with acute trigger-induced hemolytic crises, G-6-PD deficiency-associated neonatal hyperbilirubinemia has been labelled as hemolytic in origin. In this article, the authors summarize recent evidence demonstrating that hemolysis cannot in and of itself be responsible for jaundice and that decreased bilirubin elimination plays a major role in its pathogenesis.
M Kaplan; C Hammerman
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Clinics in perinatology     Volume:  25     ISSN:  0095-5108     ISO Abbreviation:  Clin Perinatol     Publication Date:  1998 Sep 
Date Detail:
Created Date:  1998-12-03     Completed Date:  1998-12-03     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  7501306     Medline TA:  Clin Perinatol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  575-90, viii     Citation Subset:  IM    
Department of Neonatology, Shaare Zedek Medical Center, Jerusalem, Israel.
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MeSH Terms
Bilirubin / metabolism
Exchange Transfusion, Whole Blood
Glucosephosphate Dehydrogenase Deficiency / complications*
Hemolysis / physiology
Infant, Newborn
Jaundice, Neonatal / etiology*,  metabolism,  therapy
Kernicterus / etiology
Risk Factors
Reg. No./Substance:

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