| Severe mitral regurgitation-relations between magnetic resonance imaging, echocardiography and natriuretic peptides. | |
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MedLine Citation:
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PMID: 17943627 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Assessment of the severity of mitral regurgitation by echocardiography can be technically demanding in certain patients and supplementary methods are therefore desirable. This study addressed the agreement between magnetic resonance imaging (MRI) and echocardiography, and their relations to natriuretic peptides (NT-proANP and NT-proBNP), in quantifying severe mitral regurgitation. METHODS: Eighteen patients with severe mitral regurgitation scheduled for surgery underwent MRI, echocardiography and assay of natriuretic peptides preoperatively for clinical assessment. RESULTS: MRI and echocardiography were comparable in measuring severity of regurgitation qualitatively but not quantitatively, mitral regurgitant fraction (mean difference 27.5 (11) ml). There was a correlation between increasing regurgitant fraction on MRI and increased levels of plasma NT-proANP and NT-proBNP. In echocardiography, increasing vena contracta width and increasing PISA correlated to increased levels of plasma NT-proANP and NT-proBNP. No other correlation was found between measures on MRI and echocardiography and natriuretic peptides. CONCLUSIONS: MRI and echocardiography were comparable grading the severity of mitral regurgitation with qualitative measures but not with quantitative measures. MRI might be a complement to echocardiography when a more distinct measure of the regurgitant volume is needed, as in paravalvular leakage. |
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Authors:
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Laila Hellgren; Johan Landelius; Mats Stridsberg; Per Kvidal; Elisabeth Ståhle; Tomas Bjerner |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Scandinavian cardiovascular journal : SCJ Volume: 42 ISSN: 1401-7431 ISO Abbreviation: Scand. Cardiovasc. J. Publication Date: 2008 Feb |
Date Detail:
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Created Date: 2008-05-06 Completed Date: 2008-07-03 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9708377 Medline TA: Scand Cardiovasc J Country: England |
Other Details:
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Languages: eng Pagination: 48-55 Citation Subset: IM |
Affiliation:
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Department of Cardiothoracic Surgery, University Hospital, Uppsala, Sweden. laila.hellgren.johansson@akademiska.se |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aorta / ultrasonography Atrial Natriuretic Factor / blood* Biological Markers / blood Echocardiography, Doppler* Female Heart Atria / pathology Heart Ventricles / pathology Humans Magnetic Resonance Imaging* Male Middle Aged Mitral Valve Insufficiency / diagnosis*, metabolism, pathology, ultrasonography Natriuretic Peptide, Brain / blood* Peptide Fragments / blood* Predictive Value of Tests Reproducibility of Results Research Design Severity of Illness Index |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Peptide Fragments; 0/pro-brain natriuretic peptide (1-76); 114471-18-0/Natriuretic Peptide, Brain; 85637-73-6/Atrial Natriuretic Factor |
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