Document Detail


Severe malaria: metabolic complications.
MedLine Citation:
PMID:  16515507     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Metabolic complications of severe malaria are some of the most important and potentially treatable manifestations of this deadly disease. The commonest metabolic complications (lactic acidosis and hypoglycaemia) arise from increased host anaerobic metabolism probably due to a mismatch between tissue oxygen supply and requirement. Optimising treatments for these complications should be guided by detailed understanding of their underlying pathophysiology, and may help to reduce the intolerably high case fatality rate of severe malaria.
Authors:
T Planche; S Krishna
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current molecular medicine     Volume:  6     ISSN:  1566-5240     ISO Abbreviation:  Curr. Mol. Med.     Publication Date:  2006 Mar 
Date Detail:
Created Date:  2006-03-06     Completed Date:  2006-05-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101093076     Medline TA:  Curr Mol Med     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  141-53     Citation Subset:  IM    
Affiliation:
Division of Cellular and Molecular Medicine, Centre for Infection, St. George's University of London, London SW17 0RE, UK. tim@planche.demon.co.uk
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MeSH Terms
Descriptor/Qualifier:
Acetylcysteine / therapeutic use
Acidosis, Lactic / parasitology
Antimalarials / therapeutic use
Dichloroacetate / therapeutic use
Humans
Hypoglycemia / parasitology
Malaria, Falciparum / complications*,  drug therapy,  metabolism*,  physiopathology
Chemical
Reg. No./Substance:
0/Antimalarials; 13425-80-4/Dichloroacetate; 616-91-1/Acetylcysteine

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