| Severe liver disease in pregnancy. | |
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MedLine Citation:
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PMID: 18321514 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To determine the clinical characteristics of patients with fulminant hepatitis of pregnancy (FHP) and acute fatty liver of pregnancy (AFLP) and analyze their correlation with pregnancy outcome. METHODS: Of 55 pregnant women with severe liver disease, 41 had FHP and 14 had AFLP. RESULTS: Jaundice was the primary manifestation for both FHP and AFLP and hepatic encephalopathy was the most significant complication for both. Disseminated intravascular coagulation, albuminuria, and prothrombin activity were found to be independent risk factors of maternal mortality for both. However, the rates of preterm labor, fetal demise, and neonatal asphyxia were lower in the FHP group. CONCLUSION: Women with FHP or AFLP are at risk for severe complications and adverse pregnancy outcome. Since the 2 conditions are managed differently, early diagnosis is essential. |
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Authors:
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Hui Chen; Li Yuan; Jianping Tan; Yukun Liu; Jianping Zhang |
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Publication Detail:
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Type: Journal Article Date: 2008-03-05 |
Journal Detail:
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Title: International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics Volume: 101 ISSN: 0020-7292 ISO Abbreviation: Int J Gynaecol Obstet Publication Date: 2008 Jun |
Date Detail:
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Created Date: 2008-05-05 Completed Date: 2008-09-17 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0210174 Medline TA: Int J Gynaecol Obstet Country: Ireland |
Other Details:
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Languages: eng Pagination: 277-80 Citation Subset: IM |
Affiliation:
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Obstetrics and Gynecology Department, The Second Affiliated Hospital of Sun Yat-Sen University, Guangdong, China. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Adolescent Adult Fatty Liver / complications*, mortality Female Fetal Death Hepatic Encephalopathy / etiology*, pathology Humans Jaundice / etiology* Liver / physiopathology Liver Failure, Acute / complications*, mortality Maternal Mortality Pregnancy Pregnancy Complications / diagnosis, etiology* Pregnancy Outcome Regression Analysis Risk Factors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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