| Severe lactic acidosis and rhabdomyolysis following metformin and ramipril overdose. | |
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MedLine Citation:
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PMID: 17251212 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We report the case of a 46-yr-old male who developed severe lactic acidosis, cardiorespiratory arrest, and rhabdomyolysis following an overdose of metformin and ramipril. The lactic acidosis was successfully treated with early high-volume continuous veno-venous haemofiltration. Rhabdomyolysis and lower limb compartment syndrome developed later. The patient otherwise made a good recovery. We discuss the management of severe lactic acidosis secondary to metformin overdose and the association with rhabdomyolysis. |
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Authors:
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M Galea; N Jelacin; K Bramham; I White |
Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: British journal of anaesthesia Volume: 98 ISSN: 0007-0912 ISO Abbreviation: Br J Anaesth Publication Date: 2007 Feb |
Date Detail:
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Created Date: 2007-01-25 Completed Date: 2007-03-06 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0372541 Medline TA: Br J Anaesth Country: England |
Other Details:
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Languages: eng Pagination: 213-5 Citation Subset: IM |
Affiliation:
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Department of Anaesthesia and Intensive Care, St Peter's Hospital, Guildford Road, Chertsey KT16 0PZ, UK. marylyse@doctors.org.uk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acidosis, Lactic
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chemically induced*,
therapy Antihypertensive Agents / poisoning* Compartment Syndromes / chemically induced Hemofiltration / methods Humans Hypoglycemic Agents / poisoning* Male Metformin / poisoning* Middle Aged Overdose Ramipril / poisoning* Rhabdomyolysis / chemically induced* Suicide, Attempted |
| Chemical | |
Reg. No./Substance:
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0/Antihypertensive Agents; 0/Hypoglycemic Agents; 657-24-9/Metformin; 87333-19-5/Ramipril |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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