Document Detail


Severe jaundice following treatment with ezetimibe.
MedLine Citation:
PMID:  18467918     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Ezetimibe is a cholesterol-lowering agent that modulates intestinal absorption of sterols. It is well tolerated but hepatic toxicity has been reported when ezetimibe is used in conjunction with a statin medication. In this case report, we report severe isolated hyperbilirubinaemia occurring in a patient with occult cirrhosis, probably owing to nonalcoholic steatohepatitis, who was treated with ezetimibe alone. The adverse event started after ezetimibe therapy was initiated and resolved when the drug was stopped. We propose a mechanism for this reaction and believe that liver function should be monitored in patients with abnormal liver tests who are treated with ezetimibe, even if they are not on concomitant treatment with a statin.
Authors:
Stephen R Ritchie; David W Orr; Peter N Black
Related Documents :
21490848 - Primary hepatosplenic large b-cell lymphoma: a rare aggressive tumor.
3527018 - Infantile subglottic hemangiomas. an update.
2473928 - Tricuspid atresia and pregnancy.
7672978 - Fatal craniocervical necrotizing fasciitis in an immunocompetent patient: a case report...
2681658 - Esophageal leiomyoma in children: two case reports and review of the literature.
25121418 - Congenital nail abnormalities: a review of the literature.
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  European journal of gastroenterology & hepatology     Volume:  20     ISSN:  0954-691X     ISO Abbreviation:  Eur J Gastroenterol Hepatol     Publication Date:  2008 Jun 
Date Detail:
Created Date:  2008-05-09     Completed Date:  2009-02-09     Revised Date:  2009-10-16    
Medline Journal Info:
Nlm Unique ID:  9000874     Medline TA:  Eur J Gastroenterol Hepatol     Country:  England    
Other Details:
Languages:  eng     Pagination:  572-3     Citation Subset:  IM    
Affiliation:
Department of Medicine, University of Auckland, New Zealand. sritchie@adhb.govt.nz
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Anticholesteremic Agents / adverse effects*
Azetidines / adverse effects*
Fatty Liver / complications
Female
Humans
Hyperbilirubinemia / complications
Jaundice / chemically induced*,  etiology
Middle Aged
Chemical
Reg. No./Substance:
0/Anticholesteremic Agents; 0/Azetidines; 163222-33-1/ezetimibe

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  What are the sensitivity and specificity of endoscopic photographs in determining completion of colo...
Next Document:  Eosinophilic cholangiopathy with concurrent eosinophilic colitis in a patient with idiopathic hypere...