Document Detail


Severe intra- and periventricular hemorrhage: role of arteriolosclerosis related to maternal smoke.
MedLine Citation:
PMID:  21744137     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
OBJECTIVE: The authors aimed to describe the atherosclerotic lesions of the cerebral arterioles as a substrate of their rupture and bleeding. METHODS: The study was performed on the brain of nine Caucasian fetal victims of intra- and periventricular hemorrhage, all grade IV, and nine control cases. RESULTS: In the nine victims of hemorrhage, the arteriolar wall structure was altered, focally transformed into a deposit of amorphous eosinophilic material. Such changes often affected the full thickness of the wall causing rupture and hemorrhage. In eight of these cases and in two victims of the control group, the mothers were heavy cigarette smokers (15-20 cigarettes/day) before and during pregnancy. CONCLUSION: The authors conclude that intra- and periventricular hemorrhage can be ascribed to the toxic effects of prenatal absorption of nicotine.
Authors:
Luigi Matturri; Donatella Mecchia; Anna M Lavezzi
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-7-9
Journal Detail:
Title:  Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery     Volume:  -     ISSN:  1433-0350     ISO Abbreviation:  -     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2011-7-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8503227     Medline TA:  Childs Nerv Syst     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
"Lino Rossi" Research Center for the Study and Prevention of Unexpected Perinatal Death and SIDS-Department of Surgical, Reconstructive and Diagnostic Sciences, University of Milan, Via della Commenda, 19, 20122, Milan, Italy, luigi.matturri@unimi.it.
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