| Severe immune haemolytic anaemia due to ceftriaxone in a patient with congenital nephrotic syndrome. | |
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MedLine Citation:
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PMID: 21450013 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Background: Severe haemolysis caused by an immune reaction to ceftriaxone has mostly been described in patients with underlying haematological or immune dysfunction. So far this situation has not been recognised in congenital nephrotic syndrome patients. Case Report: The authors present a 20-month-old boy with congenital nephrotic syndrome of the Finnish type with several previous severe infections treated with ceftriaxone, admitted for suspected sepsis. Following ceftriaxone administration he developed shock secondary to an acute haemolytic reaction, with severe anaemia. Hypersensitivity to ceftriaxone was documented through positive agglutination tests. Conclusion: Onset of haemolysis following ceftriaxone administration, particularly in a patient previously exposed to the drug, must raise the suspicion of a possible immune reaction. |
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Authors:
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Leonor Reis Boto; Ana Rita Sandes; Anabela Brites; Susana Silva; Rosário Stone; Margarida Almeida |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-3-31 |
Journal Detail:
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Title: Acta paediatrica (Oslo, Norway : 1992) Volume: - ISSN: 1651-2227 ISO Abbreviation: - Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-3-31 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9205968 Medline TA: Acta Paediatr Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Acta Paediatrica © 2011 Foundation Acta Paediatrica. |
Affiliation:
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Unidade de Nefrologia, Departamento da Criança e da Família. Departamento de Imunohemoterapia. Serviço de Imunoalergologia, Departamento de Medicina.Centro Hospitalar Lisboa Norte. |
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