Document Detail

Severe ictal hypoxemia following focal, subclinical temporal electrographic scalp seizure activity.
MedLine Citation:
PMID:  22520581     Owner:  NLM     Status:  Publisher    
Ictal hypoxemia has been reported in focal seizures and can be particularly severe during sustained seizure activity involving both hemispheres. Oxygen desaturations have been linked to sudden unexplained death in epilepsy (SUDEP). We report a 71-year-old patient with subclinical electrographic seizure discharges involving the left temporal lobe. Electrographic seizures were followed by apneas and severe oxygen desaturations below 70% SpO(2) even after cessation of electrographic scalp seizure activity, suggesting inhibition of respiratory brainstem centers outlasting neocortical seizure activity. Seizures led to disrupted night's sleep due to arousals. Our case illustrates that severe hypoxemia can occur in association with subclinical seizures involving the temporal lobe and after scalp EEG seizure activity has terminated. Electrographic seizures followed by hypoxemia, such as observed in our patient, could contribute to SUDEP without overt clinical seizure activity.
Vesela Maglajlija; Matthew C Walker; Stjepana Kovac
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-4-18
Journal Detail:
Title:  Epilepsy & behavior : E&B     Volume:  -     ISSN:  1525-5069     ISO Abbreviation:  -     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-4-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100892858     Medline TA:  Epilepsy Behav     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Elsevier Inc. All rights reserved.
Department of Clinical Neurophysiology, National Hospital for Neurology and Neurosurgery, Queen Square, London, UK.
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