Document Detail

Severe hypokinesis caused by paraneoplastic anti-Ma2 encephalitis associated with bilateral intratubular germ-cell neoplasm of the testes.
MedLine Citation:
PMID:  17269131     Owner:  NLM     Status:  MEDLINE    
We report a 40-year-old man with severe hypokinesis as paraneoplastic manifestation of a microscopic "carcinoma in situ" of the testis. The young age of the patient, along with progressive neurologic deterioration, detection of anti-Ma2 antibodies, and ultrasound findings of bilateral microcalcifications, led to bilateral orchiectomy, revealing the tumor in both testes. After orchiectomy, neurological symptoms stabilized, but the patient eventually died of systemic complications caused by his severe neurological deficits. Anti-Ma2 paraneoplastic encephalitis should be considered in patients with severe hypokinesis, and intensive investigation and aggressive approach to treatment is encouraged to prevent progression of the neurological deficits.
Lumine Matsumoto; Tomotaka Yamamoto; Mana Higashihara; Izumi Sugimoto; Hisatomo Kowa; Junji Shibahara; Koichiro Nakamura; Jun Shimizu; Yoshikazu Ugawa; Jun Goto; Josep Dalmau; Shoji Tsuji
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Movement disorders : official journal of the Movement Disorder Society     Volume:  22     ISSN:  0885-3185     ISO Abbreviation:  Mov. Disord.     Publication Date:  2007 Apr 
Date Detail:
Created Date:  2007-05-01     Completed Date:  2007-07-23     Revised Date:  2012-10-09    
Medline Journal Info:
Nlm Unique ID:  8610688     Medline TA:  Mov Disord     Country:  United States    
Other Details:
Languages:  eng     Pagination:  728-31     Citation Subset:  IM    
Department of Neurology, The University of Tokyo, Tokyo, Japan.
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MeSH Terms
Antigens, Neoplasm / immunology*
Autoantibodies / blood*
Brain / immunology,  pathology
Carcinoma in Situ / diagnosis*,  immunology,  pathology,  surgery
Disease Progression
Fatal Outcome
Hypokinesia / diagnosis*,  immunology,  pathology
Limbic Encephalitis / diagnosis*,  immunology,  pathology
Magnetic Resonance Imaging
Neoplasms, Germ Cell and Embryonal / diagnosis*,  immunology,  pathology,  surgery
Nerve Tissue Proteins / immunology*
Paraneoplastic Syndromes / diagnosis*,  immunology,  pathology
Seminiferous Tubules* / pathology
Testicular Neoplasms / diagnosis*,  immunology,  pathology,  surgery
Grant Support
R01 CA089054/CA/NCI NIH HHS; R01 CA089054-05/CA/NCI NIH HHS; R01 CA107192/CA/NCI NIH HHS; R01 CA107192-03/CA/NCI NIH HHS
Reg. No./Substance:
0/Antigens, Neoplasm; 0/Autoantibodies; 0/Ma2 antigen; 0/Nerve Tissue Proteins

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