| Severe hypoglycaemia in children and adolescents during multiple-dose insulin therapy. | |
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MedLine Citation:
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PMID: 9702475 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Episodes of severe hypoglycaemia, resulting in coma and/or convulsions, were documented in an unselected, population-based group of 376 children and adolescents with Type 1 diabetes mellitus (Type 1 DM) treated at the Aurora Hospital, City of Helsinki. A prospective study in 1994-95 yielded 493 patient-years and a retrospective study in 1990-93, 904 patient-years of data. Of these patients, 77-85% received insulin in three or more daily doses. During 1990-95, 43 patients had a total of 48 severe hypoglycaemic episodes. For each episode (n = 48), one control Type 1 DM patient who had never experienced any severe hypoglycaemia, matched by age, diabetes duration and puberty, was sought from the study population. Incidence of severe hypoglycaemia was 3.1/100 patients years prospectively and 3.6/100 retrospectively. At the time of the episode, median age was 13.3 (range 2.2-21) years, and median diabetes duration 6.1 (0.5-14.6) years. Rates were similar in different age groups (< 6, 6-12.9 and > or = 13 years). A potential explanation for the hypoglycaemia was found in 79% of the episodes. Insulin dose was higher (p = 0.04) and HbA1c lower (p = 0.005) in patients with severe hypoglycaemia than in controls. In conclusion, multiple-dose insulin therapy in young patients with Type 1 DM can be associated with a low rate of severe hypoglycaemia. The majority of such episodes seem to be preventable. |
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Authors:
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S Tupola; J Rajantie; J Mäenpää |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Diabetic medicine : a journal of the British Diabetic Association Volume: 15 ISSN: 0742-3071 ISO Abbreviation: Diabet. Med. Publication Date: 1998 Aug |
Date Detail:
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Created Date: 1998-10-26 Completed Date: 1998-10-26 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8500858 Medline TA: Diabet Med Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 695-9 Citation Subset: IM |
Affiliation:
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Aurora Hospital, Helsinki, Finland. sariman.tupola@helsinki.fi |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Alcohol Drinking Child Child, Preschool Diabetes Mellitus, Type 1 / blood*, drug therapy* Drug Administration Schedule Exercise Feeding Behavior Finland / epidemiology Hemoglobin A, Glycosylated / analysis Humans Hypoglycemia / chemically induced, epidemiology*, etiology Hypoglycemic Agents / administration & dosage, adverse effects* Incidence Infant Insulin / administration & dosage, adverse effects* Prospective Studies Retrospective Studies Seasons |
| Chemical | |
Reg. No./Substance:
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0/Hemoglobin A, Glycosylated; 0/Hypoglycemic Agents; 11061-68-0/Insulin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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