Document Detail

Severe hypoglycaemia in children and adolescents during multiple-dose insulin therapy.
MedLine Citation:
PMID:  9702475     Owner:  NLM     Status:  MEDLINE    
Episodes of severe hypoglycaemia, resulting in coma and/or convulsions, were documented in an unselected, population-based group of 376 children and adolescents with Type 1 diabetes mellitus (Type 1 DM) treated at the Aurora Hospital, City of Helsinki. A prospective study in 1994-95 yielded 493 patient-years and a retrospective study in 1990-93, 904 patient-years of data. Of these patients, 77-85% received insulin in three or more daily doses. During 1990-95, 43 patients had a total of 48 severe hypoglycaemic episodes. For each episode (n = 48), one control Type 1 DM patient who had never experienced any severe hypoglycaemia, matched by age, diabetes duration and puberty, was sought from the study population. Incidence of severe hypoglycaemia was 3.1/100 patients years prospectively and 3.6/100 retrospectively. At the time of the episode, median age was 13.3 (range 2.2-21) years, and median diabetes duration 6.1 (0.5-14.6) years. Rates were similar in different age groups (< 6, 6-12.9 and > or = 13 years). A potential explanation for the hypoglycaemia was found in 79% of the episodes. Insulin dose was higher (p = 0.04) and HbA1c lower (p = 0.005) in patients with severe hypoglycaemia than in controls. In conclusion, multiple-dose insulin therapy in young patients with Type 1 DM can be associated with a low rate of severe hypoglycaemia. The majority of such episodes seem to be preventable.
S Tupola; J Rajantie; J Mäenpää
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Diabetic medicine : a journal of the British Diabetic Association     Volume:  15     ISSN:  0742-3071     ISO Abbreviation:  Diabet. Med.     Publication Date:  1998 Aug 
Date Detail:
Created Date:  1998-10-26     Completed Date:  1998-10-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8500858     Medline TA:  Diabet Med     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  695-9     Citation Subset:  IM    
Aurora Hospital, Helsinki, Finland.
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MeSH Terms
Alcohol Drinking
Child, Preschool
Diabetes Mellitus, Type 1 / blood*,  drug therapy*
Drug Administration Schedule
Feeding Behavior
Finland / epidemiology
Hemoglobin A, Glycosylated / analysis
Hypoglycemia / chemically induced,  epidemiology*,  etiology
Hypoglycemic Agents / administration & dosage,  adverse effects*
Insulin / administration & dosage,  adverse effects*
Prospective Studies
Retrospective Studies
Reg. No./Substance:
0/Hemoglobin A, Glycosylated; 0/Hypoglycemic Agents; 11061-68-0/Insulin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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