Document Detail


Severe hypocholesterolaemia is often neglected in haematological malignancies.
MedLine Citation:
PMID:  20434328     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIM OF THE STUDY: It is generally believed that high levels of cholesterol (hypercholesterolaemia) are life-threatening, while low levels seem to be positive. Unfortunately this assumption is far from true, and can be indicative of an underlying serious medical condition in most of the cases (i.e. cancer). However, the biological role of severe hypocholesterolaemia is poorly understood. Here, the possible biological process is being investigated. Cholesterol plays a key role in cell proliferation, hence it has been suggested that low cholesterol levels are probably linked to the high cellular cholesterol demands from neoplastic cells.
SUMMARY OF THE METHODS: We used serum and isolated T-lymphocytes from patients with acute lymphoblast leukaemia and human lymphoblast cell line to test this hypothesis.
RESULTS: We found that patients with low serum cholesterol levels have instead high levels of cholesterol in lymphocytes. These data were supported with in vitro studies. In fact we have demonstrated that low cholesterol level in the culture medium was related to the neoplastic cellular growth, suggesting a greater use by lymphoma cells for their proliferation. Therefore by inhibiting cholesterol synthesis by mevastatin, in vitro, we showed that cholesterol levels did not change significantly in culture medium and the cellular growth was inhibited.
CONCLUDING STATEMENT: Following these preliminary results, blood cholesterol levels could be potentially considered a good biological marker to follow up the neoplastic process.
Authors:
Luca Pugliese; Ilaria Bernardini; Nazareno Pacifico; Manola Peverini; Eleni Damaskopoulou; Samuela Cataldi; Elisabetta Albi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-04-29
Journal Detail:
Title:  European journal of cancer (Oxford, England : 1990)     Volume:  46     ISSN:  1879-0852     ISO Abbreviation:  Eur. J. Cancer     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-06-10     Completed Date:  2010-10-06     Revised Date:  2013-11-06    
Medline Journal Info:
Nlm Unique ID:  9005373     Medline TA:  Eur J Cancer     Country:  England    
Other Details:
Languages:  eng     Pagination:  1735-43     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Elsevier Ltd. All rights reserved.
Affiliation:
Polispecialistica Bios, Crotone, Italy.
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MeSH Terms
Descriptor/Qualifier:
Adult
Anticholesteremic Agents / pharmacology
Cell Line
Cell Proliferation / drug effects
Cell Survival / drug effects
Cholesterol / blood*
Female
Humans
Lovastatin / analogs & derivatives,  pharmacology
Male
Middle Aged
Precursor Cell Lymphoblastic Leukemia-Lymphoma / blood*
T-Lymphocytes / metabolism
Young Adult
Chemical
Reg. No./Substance:
0/Anticholesteremic Agents; 1UQM1K0W9X/mevastatin; 57-88-5/Cholesterol; 75330-75-5/Lovastatin

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