Document Detail


Severe hypertension in childhood due to prolonged skin application of a mineralocorticoid ointment.
MedLine Citation:
PMID:  6746088     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We report the case of a 9-year-old boy suffering from exzematous dermatitis who was treated for 6 years with a daily dose of 100 mg of a dermatological ointment containing 9 alpha-fluoroprednisolone-21-acetate. At examination the patient's blood pressure was persistently 230/160 mm Hg and was considered essential in origin after secondary forms of arterial hypertension had been excluded. Treatment with nifedipine and labetalol lowered the blood pressure to 150/100 mm Hg. When we became aware of the dermatological treatment, we advised its discontinuance. In the subsequent 7 days, the blood pressure fell to hypotensive levels (75/40 mm Hg) and then became normal a few days after discontinuance of the antihypertensive therapy. This case suggests that prolonged use of topical steroids, commonly prescribed for skin diseases, may cause hypertension, especially in childhood.
Authors:
A Bartorelli; A Rimondini
Related Documents :
17967968 - Impact of human factor design on the use of order sets in the treatment of congestive h...
1723468 - Nitrendipine once or twice daily in hypertensive non-insulin-dependent diabetes mellitus.
1375678 - Syst-eur--a multicenter trial on the treatment of isolated systolic hypertension in the...
10977788 - Lack of seasonal variation in blood pressure in patients on hemodialysis in a north ame...
15853118 - Can foods with added soya-protein or fish-oil reduce risk factors for coronary disease?...
25090658 - Pressure tuning the fermi level through the dirac point of giant rashba semiconductor b...
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Hypertension     Volume:  6     ISSN:  0194-911X     ISO Abbreviation:  Hypertension     Publication Date:    1984 Jul-Aug
Date Detail:
Created Date:  1984-09-14     Completed Date:  1984-09-14     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7906255     Medline TA:  Hypertension     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  586-8     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Administration, Topical
Blood Pressure / drug effects
Child
Eczema / drug therapy
Fluprednisolone / administration & dosage,  adverse effects,  analogs & derivatives*
Humans
Hypertension / chemically induced*,  drug therapy
Labetalol / therapeutic use
Male
Nifedipine / therapeutic use
Time Factors
Chemical
Reg. No./Substance:
21829-25-4/Nifedipine; 338-98-7/biorinil; 36894-69-6/Labetalol; 53-34-9/Fluprednisolone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Vasomotion of renal blood flow in essential hypertension. Oscillations in xenon transit.
Next Document:  Properties of crude Campylobacter jejuni heat-labile enterotoxin.