Document Detail

Severe hypertension in childhood due to prolonged skin application of a mineralocorticoid ointment.
MedLine Citation:
PMID:  6746088     Owner:  NLM     Status:  MEDLINE    
We report the case of a 9-year-old boy suffering from exzematous dermatitis who was treated for 6 years with a daily dose of 100 mg of a dermatological ointment containing 9 alpha-fluoroprednisolone-21-acetate. At examination the patient's blood pressure was persistently 230/160 mm Hg and was considered essential in origin after secondary forms of arterial hypertension had been excluded. Treatment with nifedipine and labetalol lowered the blood pressure to 150/100 mm Hg. When we became aware of the dermatological treatment, we advised its discontinuance. In the subsequent 7 days, the blood pressure fell to hypotensive levels (75/40 mm Hg) and then became normal a few days after discontinuance of the antihypertensive therapy. This case suggests that prolonged use of topical steroids, commonly prescribed for skin diseases, may cause hypertension, especially in childhood.
A Bartorelli; A Rimondini
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Hypertension     Volume:  6     ISSN:  0194-911X     ISO Abbreviation:  Hypertension     Publication Date:    1984 Jul-Aug
Date Detail:
Created Date:  1984-09-14     Completed Date:  1984-09-14     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7906255     Medline TA:  Hypertension     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  586-8     Citation Subset:  IM    
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MeSH Terms
Administration, Topical
Blood Pressure / drug effects
Eczema / drug therapy
Fluprednisolone / administration & dosage,  adverse effects,  analogs & derivatives*
Hypertension / chemically induced*,  drug therapy
Labetalol / therapeutic use
Nifedipine / therapeutic use
Time Factors
Reg. No./Substance:
21829-25-4/Nifedipine; 338-98-7/biorinil; 36894-69-6/Labetalol; 53-34-9/Fluprednisolone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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