| Severe hypercalcemia associated with uterine leiomyoma in pregnancy. | |
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MedLine Citation:
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PMID: 21252794 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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BACKGROUND: : Uterine leiomyomas are the most common pelvic tumor, and a frequent indication of the need for gynecologic surgery. Although usually asymptomatic, life-threatening cases can occur. We present a case of critical hypercalcemia associated with a leiomyoma during pregnancy with the intention of highlighting the endocrinology of leiomyomas, features shared with malignant neoplasms, and the potential for effects on obstetric outcomes. CASE: : A 32-year-old gravid woman with a large leiomyoma presented at 33 5/7 weeks of gestation with critical hypercalcemia requiring intensive care. Postpartum myomectomy cured her hypercalcemia, which was driven by parathyroid hormone-related protein (PTHrP) produced by the tumor. CONCLUSION: : Obstetricians should be aware of the existence of humoral hypercalcemia related to leiomyomas and the potential effects on pregnancy. |
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Authors:
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Edward Tarnawa; Scott Sullivan; Paul Underwood; Mary Richardson; Laura Spruill |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Obstetrics and gynecology Volume: 117 ISSN: 1873-233X ISO Abbreviation: Obstet Gynecol Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-01-21 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0401101 Medline TA: Obstet Gynecol Country: United States |
Other Details:
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Languages: eng Pagination: 473-6 Citation Subset: AIM; IM |
Affiliation:
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From the Departments of Obstetrics and Gynecology and Pathology, Medical University of South Carolina, Charleston, South Carolina. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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