| Severe hypercalcaemia in B-cell lymphoma: combined effects of PTH-rP, IL-6 and TNF. | |
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MedLine Citation:
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PMID: 10621879 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Hypercalcaemia as the only manifestation of B-cell lymphoma is seen very rarely. Its pathophysiology is heterogenous and not well understood. We report a 73-year-old man who presented with severe hypercalcaemia before any signs of malignancy became evident. He was diagnosed with a B-cell lymphoma on bone marrow trephine biopsy. The hypercalcaemia was associated with high plasma concentrations of parathyroid-hormone-related protein, interleukin-6 and tumour necrosis factor. Our patient had markedly increased osteoclast and osteoblast activity as a result of synergistic effects between these factors, with consequent severe hypercalcaemia. This is the first reported example of such combined effects of these factors in humans. |
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Authors:
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A Daroszewska; R C Bucknall; P Chu; W D Fraser |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Postgraduate medical journal Volume: 75 ISSN: 0032-5473 ISO Abbreviation: Postgrad Med J Publication Date: 1999 Nov |
Date Detail:
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Created Date: 2000-01-21 Completed Date: 2000-01-21 Revised Date: 2009-10-22 |
Medline Journal Info:
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Nlm Unique ID: 0234135 Medline TA: Postgrad Med J Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 672-4 Citation Subset: IM |
Affiliation:
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Royal Liverpool University Hospital, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Antineoplastic Combined Chemotherapy Protocols / administration & dosage Bone Marrow Cells C-Reactive Protein / analysis, metabolism Cyclophosphamide / administration & dosage Doxorubicin / administration & dosage Humans Hypercalcemia / drug therapy, etiology*, metabolism Interleukin-6 / blood, metabolism* Lymphoma, B-Cell / complications*, drug therapy, metabolism Male Neoplasm Proteins / metabolism* Osteoblasts / pathology Osteoclasts / pathology Parathyroid Hormone-Related Protein Prednisone / administration & dosage Proteins / metabolism* Tumor Necrosis Factor-alpha / analysis, metabolism* Vincristine / administration & dosage |
| Chemical | |
Reg. No./Substance:
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0/CHOP protocol; 0/Interleukin-6; 0/Neoplasm Proteins; 0/PTHLH protein, human; 0/Parathyroid Hormone-Related Protein; 0/Proteins; 0/Tumor Necrosis Factor-alpha; 23214-92-8/Doxorubicin; 50-18-0/Cyclophosphamide; 53-03-2/Prednisone; 57-22-7/Vincristine; 9007-41-4/C-Reactive Protein |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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