Document Detail

Severe hypercalcaemia in B-cell lymphoma: combined effects of PTH-rP, IL-6 and TNF.
MedLine Citation:
PMID:  10621879     Owner:  NLM     Status:  MEDLINE    
Hypercalcaemia as the only manifestation of B-cell lymphoma is seen very rarely. Its pathophysiology is heterogenous and not well understood. We report a 73-year-old man who presented with severe hypercalcaemia before any signs of malignancy became evident. He was diagnosed with a B-cell lymphoma on bone marrow trephine biopsy. The hypercalcaemia was associated with high plasma concentrations of parathyroid-hormone-related protein, interleukin-6 and tumour necrosis factor. Our patient had markedly increased osteoclast and osteoblast activity as a result of synergistic effects between these factors, with consequent severe hypercalcaemia. This is the first reported example of such combined effects of these factors in humans.
A Daroszewska; R C Bucknall; P Chu; W D Fraser
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Postgraduate medical journal     Volume:  75     ISSN:  0032-5473     ISO Abbreviation:  Postgrad Med J     Publication Date:  1999 Nov 
Date Detail:
Created Date:  2000-01-21     Completed Date:  2000-01-21     Revised Date:  2009-10-22    
Medline Journal Info:
Nlm Unique ID:  0234135     Medline TA:  Postgrad Med J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  672-4     Citation Subset:  IM    
Royal Liverpool University Hospital, UK.
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MeSH Terms
Antineoplastic Combined Chemotherapy Protocols / administration & dosage
Bone Marrow Cells
C-Reactive Protein / analysis,  metabolism
Cyclophosphamide / administration & dosage
Doxorubicin / administration & dosage
Hypercalcemia / drug therapy,  etiology*,  metabolism
Interleukin-6 / blood,  metabolism*
Lymphoma, B-Cell / complications*,  drug therapy,  metabolism
Neoplasm Proteins / metabolism*
Osteoblasts / pathology
Osteoclasts / pathology
Parathyroid Hormone-Related Protein
Prednisone / administration & dosage
Proteins / metabolism*
Tumor Necrosis Factor-alpha / analysis,  metabolism*
Vincristine / administration & dosage
Reg. No./Substance:
0/CHOP protocol; 0/Interleukin-6; 0/Neoplasm Proteins; 0/PTHLH protein, human; 0/Parathyroid Hormone-Related Protein; 0/Proteins; 0/Tumor Necrosis Factor-alpha; 23214-92-8/Doxorubicin; 50-18-0/Cyclophosphamide; 53-03-2/Prednisone; 57-22-7/Vincristine; 9007-41-4/C-Reactive Protein

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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