| Severe high-density lipoprotein deficiency associated with autoantibodies against lecithin:cholesterol acyltransferase in non-hodgkin lymphoma. | |
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MedLine Citation:
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PMID: 22271127 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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An antibody against the lecithin:cholesterol acyltransferase (LCAT) enzyme, which negates cholesterol esterification in plasma, causing severe high-density lipoprotein deficiency (HD), was identified in a woman with a large-cell non-Hodgkin lymphoma. Successful treatment of the lymphoma resulted in clearance of the antibody and complete correction of the defective cholesterol esterification and HD. To our knowledge, an acquired LCAT deficiency leading to severe HD has not been reported previously in association with a malignant disease, and this patient represents the first such documented case. |
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Authors:
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Sara Simonelli; Elisabetta Gianazza; Giuliana Mombelli; Alighiero Bondioli; Giovanni Ferraro; Silvana Penco; Cesare R Sirtori; Guido Franceschini; Laura Calabresi |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Archives of internal medicine Volume: 172 ISSN: 1538-3679 ISO Abbreviation: Arch. Intern. Med. Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-01-24 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0372440 Medline TA: Arch Intern Med Country: United States |
Other Details:
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Languages: eng Pagination: 179-81 Citation Subset: AIM; IM |
Affiliation:
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Center E. Grossi Paoletti, Department of Pharmacological Sciences, Università degli Studi di Milano, via Balzaretti 9, 20133 Milano, Italy. laura.calabresi@unimi.it. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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