Document Detail

Severe hemorrhagic complication due to acquired factor V inhibitor after single exposure to bovine thrombin product.
MedLine Citation:
PMID:  11678459     Owner:  NLM     Status:  MEDLINE    
Hemorrhagic complications have been reported after repeated exposures to bovine thrombin products due to development of factor V inhibitors. Our patient underwent emergency repair of acute aortic dissection and coronary artery bypass grafting. The patient developed leg wound infection at the saphenous vein harvest site, which was debrided and left open. Attempt to reclose the leg wound 1 month later was complicated by a life-threatening hemorrhage with markedly elevated activated partial thromboplastin time. There was no evidence of infection or disseminated intravascular coagulation, and further study identified low factor V level with positive factor V inhibitor. Treatment with plasmapheresis and steroid successfully reversed the coagulopathy. Detailed case review failed to reveal exposure to any thrombin products other than the one used for the aortic dissection repair. This case was unusual because only a single exposure to this product resulted in severe hemorrhagic complication 1 month after surgery.
M Kajitani; A Ozdemir; M Aguinaga; A R Jazieh; J T Flick; T Antakli
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of cardiac surgery     Volume:  15     ISSN:  0886-0440     ISO Abbreviation:  J Card Surg     Publication Date:    2000 Nov-Dec
Date Detail:
Created Date:  2001-10-25     Completed Date:  2002-01-29     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8908809     Medline TA:  J Card Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  378-82     Citation Subset:  IM    
Division of Cardiothoracic Surgery, University of Arkansas for Medical Sciences, Little Rock 72205-7199, USA.
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MeSH Terms
Aneurysm, Dissecting / surgery
Aortic Aneurysm / surgery
Blood Coagulation Disorders / etiology*
Coronary Artery Bypass
Factor V / antagonists & inhibitors*
Fibrin Tissue Adhesive / adverse effects
Middle Aged
Postoperative Hemorrhage / etiology*
Surgical Wound Infection / complications
Thrombin / administration & dosage,  adverse effects*
Reg. No./Substance:
0/Fibrin Tissue Adhesive; 9001-24-5/Factor V; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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