| Severe hemorrhagic bullous lesions in Henoch Schonlein purpura: three pediatric cases and review of the literature. | |
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MedLine Citation:
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PMID: 19609528 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Henoch Schonlein purpura (HSP) is a small-sized blood vessels vasculitis, resulting from immunoglobulin A-mediated inflammation. It is the most common acute systemic vasculitis in childhood and mainly affects skin, gastrointestinal tract, joints and kidney. Skin lesions, usually presenting as erythematous maculopapules, petechiae, and purpura, often involve lower extremities and buttocks, but may also extend to the upper extremities, face and trunk. Conversely to adults, hemorrhagic bullous evolution has been seldom described in childhood. The pressure is likely a factor into the pathogenesis of bullae. We report on three new pediatric cases of HSP with hemorrhagic bullous skin lesions, and a review of the literature. Bullous evolution represents an unusual, but well-recognized cutaneous manifestation that may be a source of diagnostic dilemma, but does not seem to have any prognostic value in the outcome of HSP. |
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Authors:
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Sandra Trapani; Paola Mariotti; Massimo Resti; Lido Nappini; Maurizio de Martino; Fernanda Falcini |
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Publication Detail:
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Type: Case Reports; Journal Article; Review Date: 2009-07-16 |
Journal Detail:
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Title: Rheumatology international Volume: 30 ISSN: 1437-160X ISO Abbreviation: Rheumatol. Int. Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-07-23 Completed Date: 2010-10-28 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8206885 Medline TA: Rheumatol Int Country: Germany |
Other Details:
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Languages: eng Pagination: 1355-9 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, Anna Meyer Children's Hospital Florence, University of Florence, Via Luca Giordano 13, 50132, Florence, Italy. sandra.trapani@unifi.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Azathioprine
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therapeutic use Blister / complications, drug therapy, pathology* Child Female Glucocorticoids / therapeutic use Hemorrhage / complications, drug therapy, pathology* Humans Immunosuppressive Agents / therapeutic use Male Prednisone / therapeutic use Prognosis Purpura, Schoenlein-Henoch / complications, drug therapy, pathology* Remission, Spontaneous Skin / pathology* Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Glucocorticoids; 0/Immunosuppressive Agents; 446-86-6/Azathioprine; 53-03-2/Prednisone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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