Document Detail

Severe hemolytic disease from rhesus anti-C antibodies in a surrogate pregnancy after oocyte donation. A case report.
MedLine Citation:
PMID:  10319314     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Maternal sensitization with rhesus anti-C antibodies is comparatively rare and usually benign. In pregnancies conceived using donor oocytes, the mother's blood group may differ from that of both the father and the oocyte donor, making blood group incompatibility more likely. CASE: Twins, the result of a surrogate pregnancy using donor oocytes, were born with severe hemolytic disease due to rhesus anti-C antibodies. Both infants required exchange transfusion for profound anemia at birth. Isoimmunization in the surrogate mother was not detected antenatally. The twins were delivered by emergency cesarean section due to fetal compromise, detected fortuitously when the mother attended for routine fetal assessment at 35 weeks' gestation. CONCLUSION: Isoimmunization with anti-C antibodies is not always benign and may cause significant hemolytic disease. With the success of in vitro fertilization and oocyte donation, more infertile couples may use these methods to conceive, with or without surrogacy arrangements. In such cases, the provision of antenatal care may become a complex matter, involving several parties, and good communication between everyone involved is vital. In pregnancies conceived with donor oocytes, there may be a higher risk of blood group incompatibility, and special vigilance is warranted.
S Mitchell; A James
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The Journal of reproductive medicine     Volume:  44     ISSN:  0024-7758     ISO Abbreviation:  J Reprod Med     Publication Date:  1999 Apr 
Date Detail:
Created Date:  1999-06-29     Completed Date:  1999-06-29     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0173343     Medline TA:  J Reprod Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  388-90     Citation Subset:  IM    
Department of Paediatrics, City Hospital, Birmingham, U.K.
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MeSH Terms
Cesarean Section
Diseases in Twins / etiology*,  therapy
Erythroblastosis, Fetal / etiology*,  therapy
Exchange Transfusion, Whole Blood
Fertilization in Vitro
Fetal Distress / etiology,  therapy
Infant, Newborn
Isoantibodies / immunology*
Oocyte Donation / adverse effects*
Rh Isoimmunization / etiology*,  therapy
Risk Factors
Surrogate Mothers*
Reg. No./Substance:
0/Isoantibodies; 0/anti-c antibody

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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