| Severe hemolysis and methemoglobinemia following fava beans ingestion in glucose-6-phosphatase dehydrogenase deficiency: case report and literature review. | |
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MedLine Citation:
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PMID: 19263080 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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INTRODUCTION: Reduced concentrations of glucose-6-phospate dehydrogenase (G6PD) render erythrocytes susceptible to hemolysis under conditions of oxidative stress. In favism, the ingestion of fava beans induces an oxidative stress to erythrocytes, leading to acute hemolysis. DISCUSSION: The simultaneous occurrence of methemoglobinemia has been reported only scarcely, despite the fact that both phenomena are the consequence of a common pathophysiologic mechanism. The presence of methemoglobinemia has important diagnostic and therapeutic consequences. We report a previously healthy boy who presented with combined severe hemolytic anemia and cyanosis due to methemoglobinemia, following the ingestion of fava beans. His condition was complicated by the development of transient acute renal failure. A G6PD-deficiency was diagnosed. We review the literature on the combination of acute hemolysis and methemoglobinemia in favism. Pathophysiologic, diagnostic, and therapeutic aspects of this disorder are discussed. |
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Authors:
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Marijn Schuurman; Dick van Waardenburg; Joost Da Costa; Hendrik Niemarkt; Piet Leroy |
Publication Detail:
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Type: Case Reports; Journal Article; Review Date: 2009-03-05 |
Journal Detail:
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Title: European journal of pediatrics Volume: 168 ISSN: 1432-1076 ISO Abbreviation: Eur. J. Pediatr. Publication Date: 2009 Jul |
Date Detail:
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Created Date: 2009-05-14 Completed Date: 2009-08-19 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7603873 Medline TA: Eur J Pediatr Country: Germany |
Other Details:
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Languages: eng Pagination: 779-82 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, Atrium Medical Centre Heerlen, Heerlen, The Netherlands. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Cyanosis
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etiology,
physiopathology Favism / enzymology, genetics Glycogen Storage Disease Type I / diagnosis*, physiopathology*, therapy Hemolysis* Humans Infant Kidney Failure, Acute / etiology, physiopathology Male Methemoglobinemia / complications*, etiology*, physiopathology Risk Factors Vicia faba / adverse effects* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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