Document Detail

Severe generalized hyperkinesia to nicardipine SR therapy.
MedLine Citation:
PMID:  7874376     Owner:  NLM     Status:  MEDLINE    
A patient who was taking nicardipine SR for angina management suffered two episodes of severe involuntary tonic and clonic muscular contractions, involving both upper extremities and torso without loss of consciousness. This tardive dyskinesia occurred in the absence of hypotension and cardiac rhythm disorder. Intravenous diazepam promptly controlled these symptoms. The precise etiology of the dyskinesia is not clear and its relation to nicardipine remains speculative as the patient refused rechallenge with the drug. Possible hypothesis for tardive dyskinesia and nicardipine are presented.
G Das
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  International journal of clinical pharmacology and therapeutics     Volume:  32     ISSN:  0946-1965     ISO Abbreviation:  Int J Clin Pharmacol Ther     Publication Date:  1994 Nov 
Date Detail:
Created Date:  1995-04-04     Completed Date:  1995-04-04     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9423309     Medline TA:  Int J Clin Pharmacol Ther     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  612-3     Citation Subset:  IM    
UND School of Medicine, Fargo.
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MeSH Terms
Angina Pectoris / drug therapy
Delayed-Action Preparations
Diazepam / therapeutic use
Dyskinesia, Drug-Induced / drug therapy,  etiology*
Nicardipine / adverse effects*
Reg. No./Substance:
0/Delayed-Action Preparations; 439-14-5/Diazepam; 55985-32-5/Nicardipine

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