Document Detail

Severe gastrointestinal bleeding in a uremic patient treated with estrogen-progesterone therapy.
MedLine Citation:
PMID:  10467929     Owner:  NLM     Status:  MEDLINE    
Gastrointestinal bleeding is a frequent complication in hemodialysis patients; angiodysplasia is a potential cause, with a higher incidence in uremic patients. We describe a case of severe anemia (Hemoglobin up to 3.5 g/dl) secondary to diffuse angiodysplastic lesions in a hemodialysis patient with mixed connective tissue disease. The case is characterised both by the severity of the clinical picture (extension and entity of angiodysplastic lesions, frequency of bleeding episodes) and by the patient's religious faith which made her reject blood transfusions. We underline the efficacy of estrogen-progesterone therapy in view of the modest results obtained with other therapeutic strategies on bleeding.
G Mosconi; E Mambelli; F Zanchelli; E Isola; C Perna; A De Pascalis; C Raimondi; M Ventrucci; S Stefoni
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The International journal of artificial organs     Volume:  22     ISSN:  0391-3988     ISO Abbreviation:  Int J Artif Organs     Publication Date:  1999 May 
Date Detail:
Created Date:  1999-10-20     Completed Date:  1999-10-20     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7802649     Medline TA:  Int J Artif Organs     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  313-6     Citation Subset:  IM    
Department of Clinical Medicine and Applied Biotechnology, S. Orsola University Hospital, Bologna, Italy.
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MeSH Terms
Anemia / etiology
Angiodysplasia / complications,  drug therapy
Drug Therapy, Combination
Estradiol / administration & dosage,  adverse effects,  analogs & derivatives*
Gastrointestinal Hemorrhage / drug therapy*,  etiology*
Mixed Connective Tissue Disease / complications
Norethindrone / administration & dosage*,  adverse effects
Progesterone Congeners / administration & dosage*,  adverse effects
Renal Dialysis / adverse effects
Uremia / complications*,  therapy
Reg. No./Substance:
0/Progesterone Congeners; 0/ethylenestradiol; 50-28-2/Estradiol; 68-22-4/Norethindrone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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