Document Detail

Severe gastrointestinal bleeding during pregnancy in a case of blue rubber bleb nevus syndrome.
MedLine Citation:
PMID:  16052398     Owner:  NLM     Status:  MEDLINE    
Blue rubber bleb nevus syndrome (BRBNS) is a rare disorder characterized by distinctive cutaneous and gastrointestinal venous malformations that usually cause massive or occult gastrointestinal hemorrhage and iron deficiency anemia secondary to the bleeding episodes. Only two reports of BRBNS in pregnant women can be found, according to the MEDLINE search. Both cases did not describe severe complications during pregnancy. This is the first case report of BRBNS with severe intestinal hemorrhage in a pregnant woman. The woman had been symptom-free for 5 years before the pregnancy and remained symptom-free for 2 years after delivery. This suggests that pregnancy induced the hemangiomas of the gastrointestinal tract to bleed. Celiotomy was needed to deal with massive gastrointestinal bleeding. We propose that women with BRBNS should be checked for systemic hemangiomas before pregnancy. However, it is difficult to check the small intestine thoroughly for hemangioma. Therefore, adequate attention needs to be paid to possible gastrointestinal bleeding when caring for patients with this condition. Our experience suggests that when dealing with pregnant women with BRBNS, it is essential to bear in mind the possibility that pregnancy may trigger the symptoms of hemangioma to become manifest, possibly causing life-threatening massive bleeding from the digestive tract.
Makoto Kanai; Masami Noike; Chiho Masaki; Naoko Kita; Takashi Ashida; Takao Kobayashi; Ikuo Konishi
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Seminars in thrombosis and hemostasis     Volume:  31     ISSN:  0094-6176     ISO Abbreviation:  Semin. Thromb. Hemost.     Publication Date:  2005 Jun 
Date Detail:
Created Date:  2005-07-29     Completed Date:  2005-10-18     Revised Date:  2006-03-07    
Medline Journal Info:
Nlm Unique ID:  0431155     Medline TA:  Semin Thromb Hemost     Country:  United States    
Other Details:
Languages:  eng     Pagination:  284-9     Citation Subset:  IM    
Instructor, Department of Obstetrics and Gynecology, Shinshu University School of Medicine, Matsumoto, Nagano.
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MeSH Terms
Endoscopy, Gastrointestinal
Gastrointestinal Hemorrhage / etiology*,  pathology,  therapy
Hemangioma / complications*
Magnetic Resonance Imaging
Nevus / complications*
Pregnancy Complications, Hematologic / etiology*
Pregnancy Complications, Neoplastic*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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