| Severe gamma-hydroxybutyrate withdrawal: a case report and literature review. | |
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MedLine Citation:
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PMID: 10645841 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We report a case of gamma-hydroxybutyrate (GHB) withdrawal resulting in severe agitation, mental status changes, elevated blood pressure, and tachycardia hours after stopping chronic use of GHB. The patient admitted to substantial GHB abuse on a daily basis for 2.5 years. Previous attempts at cessation reportedly resulted in diaphoresis, tremors, and agitation. The patient's symptoms, negative polypharmacy history, and negative urine and blood toxicological analysis for alcohol, benzodiazepines, sedative-hypnotics, or other substances suggested the diagnosis of GHB withdrawal. Later analysis of a patient drug sample confirmed the presence of GHB. The patient required 507 mg of lorazepam and 120 mg of diazepam over 90 h to control agitation. This is one of the few reported cases of GHB withdrawal and one of the most severe. Given the increasing use of GHB, more cases of severe GHB withdrawal should be anticipated. |
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Authors:
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K Craig; H F Gomez; J L McManus; T C Bania |
Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: The Journal of emergency medicine Volume: 18 ISSN: 0736-4679 ISO Abbreviation: J Emerg Med Publication Date: 2000 Jan |
Date Detail:
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Created Date: 2000-02-07 Completed Date: 2000-02-07 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8412174 Medline TA: J Emerg Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 65-70 Citation Subset: IM |
Affiliation:
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Department of Emergency Medicine of St. Luke's-Roosevelt Hospital, New York, New York, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Akathisia, Drug-Induced / etiology Anti-Anxiety Agents / administration & dosage Autonomic Nervous System Diseases / chemically induced* Emergencies GABA Modulators / administration & dosage Hallucinations / chemically induced Humans Hypertension / chemically induced Lorazepam / administration & dosage Male Sodium Oxybate / adverse effects* Substance Withdrawal Syndrome* / therapy Tachycardia / chemically induced Tremor / chemically induced* |
| Chemical | |
Reg. No./Substance:
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0/Anti-Anxiety Agents; 0/GABA Modulators; 502-85-2/Sodium Oxybate; 846-49-1/Lorazepam |
| Comments/Corrections | |
Comment In:
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J Emerg Med. 2001 May;20(4):418-20
[PMID:
11396429
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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