Document Detail

Severe fenthion intoxications due to ingestion and inhalation with survival outcome.
MedLine Citation:
PMID:  12046724     Owner:  NLM     Status:  MEDLINE    
Two cases of severe fenthion intoxication are presented. The first is a case of a psychiatric patient who attempted suicide with ingestion of the compound, and the second case was of a child exposed to the chemical agent by air spraying. Both patients were treated in the intensive care unit with atropine and pralidoxime and finally survived. Fenthion blood levels on admission were 2.7 and 0.95 microg/mL, respectively. Different concentrations of pralidoxime were added to the first patient's poisoned serum in order to assess in vitro the effect of pralidoxime on cholinesterase reactivation. The clinical and toxicological data of the poisonings are discussed, as well as the potential therapeutic use of pralidoxime in organophosphate intoxication.
A M Tsatsakis; G K Bertsias; V Liakou; I N Mammas; I Stiakakis; G N Tzanakakis
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Human & experimental toxicology     Volume:  21     ISSN:  0960-3271     ISO Abbreviation:  Hum Exp Toxicol     Publication Date:  2002 Jan 
Date Detail:
Created Date:  2002-06-05     Completed Date:  2002-11-14     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9004560     Medline TA:  Hum Exp Toxicol     Country:  England    
Other Details:
Languages:  eng     Pagination:  49-54     Citation Subset:  IM    
Laboratory of Toxicology, Medical School, University of Crete, Heraklion, Greece.
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MeSH Terms
Administration, Oral
Antidotes / therapeutic use*
Atropine / therapeutic use*
Environmental Exposure / adverse effects
Fenthion / administration & dosage,  blood,  poisoning*
Inhalation Exposure
Insecticides / administration & dosage,  poisoning*
Intensive Care Units
Poisoning / drug therapy*
Pralidoxime Compounds / therapeutic use*
Suicide, Attempted
Treatment Outcome
Reg. No./Substance:
0/Antidotes; 0/Insecticides; 0/Pralidoxime Compounds; 51-55-8/Atropine; 55-38-9/Fenthion; 6735-59-7/pralidoxime

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