| Severe facial clefts in acrofacial dysostosis: a consequence of prenatal exposure to mycophenolate mofetil? | |
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MedLine Citation:
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PMID: 18238994 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Immunosuppressants are teratogenic in mice, rats, and rabbits and cause prenatal growth restriction in humans. As yet, there has been no proven teratogenicity in humans. CASE: We present a chromosomally normal fetus with severe acrofacial dysostosis and orofacial clefts. These were bilateral transverse and oblique clefts and defects of the midface. In addition, there were preaxial limb anomalies with digitalization of thumbs and internal cardiovascular, gastrointestinal, and urogenital malformations. The mother had been treated with high doses of the immunosuppressant mycophenolate mofetil in early pregnancy for systemic lupus erythematosus. CONCLUSION: Mycophenolate mofetil may have contributed to or even caused acrofacial dysostosis phenotype and extensive clefting. |
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Authors:
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Katharina Schoner; Johannes Steinhard; Jens Figiel; Helga Rehder |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Obstetrics and gynecology Volume: 111 ISSN: 0029-7844 ISO Abbreviation: Obstet Gynecol Publication Date: 2008 Feb |
Date Detail:
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Created Date: 2008-02-01 Completed Date: 2008-03-27 Revised Date: 2009-10-26 |
Medline Journal Info:
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Nlm Unique ID: 0401101 Medline TA: Obstet Gynecol Country: United States |
Other Details:
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Languages: eng Pagination: 483-6 Citation Subset: AIM; IM |
Affiliation:
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Institute of Pathology, Philipps-University Marburg, Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Abnormalities, Drug-Induced
/
etiology,
pathology* Adolescent Craniofacial Abnormalities / chemically induced*, pathology Female Fetal Diseases / chemically induced*, pathology Humans Immunosuppressive Agents / adverse effects* Lupus Erythematosus, Systemic / drug therapy Mycophenolic Acid / adverse effects, analogs & derivatives* Pregnancy Pregnancy Complications / drug therapy Prenatal Exposure Delayed Effects / chemically induced*, pathology |
| Chemical | |
Reg. No./Substance:
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0/Immunosuppressive Agents; 128794-94-5/mycophenolate mofetil; 24280-93-1/Mycophenolic Acid |
| Comments/Corrections | |
Comment In:
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Obstet Gynecol. 2008 Feb;111(2 Pt 2):479-80
[PMID:
18238992
]
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Erratum In:
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Obstet Gynecol. 2008 Apr;111(4):996 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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