Document Detail

Severe electrocardiographic abnormalities during arfonad administration.
MedLine Citation:
PMID:  6526209     Owner:  NLM     Status:  MEDLINE    
Severe and reversible electrocardiographic abnormalities (first degree atrioventricular block, left bundle branch block, ventricular fibrillation), were induced by the administration of Arfonad in a patient with type III acute aortic dissection previously chronically treated with alpha-methyl-dopa. Any other possible cause of the electrocardiographic changes was excluded on the basis of clinical findings and laboratory studies. The explanation of the electrocardiographic abnormalities induced by Arfonad are not readily apparent, also on careful review of the literature. We suggest a strict electrocardiographic monitoring during Arfonad administration especially in patients with cardiac conduction defects and previous administration of cardiac cathecholamines depleting drugs.
M Di Leo; M Dalmasso; L Libero; S Bergerone; A Brusca
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Giornale italiano di cardiologia     Volume:  14     ISSN:  0046-5968     ISO Abbreviation:  G Ital Cardiol     Publication Date:  1984 Nov 
Date Detail:
Created Date:  1985-04-05     Completed Date:  1985-04-05     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  1270331     Medline TA:  G Ital Cardiol     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  931-4     Citation Subset:  IM    
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MeSH Terms
Bundle-Branch Block / chemically induced
Heart Block / chemically induced*
Trimethaphan / adverse effects*
Vasodilator Agents / adverse effects*
Ventricular Fibrillation / chemically induced*
Reg. No./Substance:
0/Vasodilator Agents; 68-91-7/trimethaphan camsylate; 7187-66-8/Trimethaphan

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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