Document Detail

Severe diarrhea due to Isospora belli in a patient with thymoma.
MedLine Citation:
PMID:  20422140     Owner:  NLM     Status:  MEDLINE    
Opportunistic isosporidial infection of the gastrointestinal tract is frequently encountered in patients with acquired immunodeficiency syndrome (AIDS) and is considered to be an AIDS-defining illness. Chronic severe watery diarrhea due to Isospora belli has also been reported in other immunodeficiency states. This report describes severe chronic debilitating diarrhea due to isosporiasis in a patient with mediastinal thymoma, a common tumor of the anterior mediastinum, originating from the epithelial cells of the thymus. Numerous oocysts of I. belli were detected in direct smear preparation of the diarrheic stool sample of the patient, who had an 8-month history of recurrent diarrhea. Duodenal and colonic mucosal biopsies revealed slight degrees of atrophic changes associated with infiltration of the lamina propria by an appreciable number of eosinophiles and the presence of unizoit tissue cysts of I. belli in the surface epithelium of the duodenal mucosa. The patient was first treated with trimethoprim-sulfamethoxazole and subsequently underwent complete thymectomy. Later, due to recurrence of the diarrhea, he was treated with ciprofloxacin.
Ahmad Reza Meamar; Mostafa Rezaian; Ali Zare Mirzaei; Farzaneh Zahabiun; Amir Hossein Faghihi; Hormazd Oormazdi; Eshrat Beigom Kia
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi     Volume:  42     ISSN:  1995-9133     ISO Abbreviation:  J Microbiol Immunol Infect     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2010-04-27     Completed Date:  2010-07-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100956211     Medline TA:  J Microbiol Immunol Infect     Country:  England    
Other Details:
Languages:  eng     Pagination:  526-9     Citation Subset:  IM    
Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran.
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MeSH Terms
Diarrhea / complications*,  parasitology
Feces / parasitology
Isosporiasis / complications*,  diagnosis,  parasitology
Thymoma / complications*,  parasitology
Thymus Neoplasms / complications*,  parasitology

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