Document Detail

Severe delirium due to basal forebrain vascular lesion and efficacy of donepezil.
MedLine Citation:
PMID:  15610933     Owner:  NLM     Status:  MEDLINE    
A severe intractable delirium caused by the basal forebrain vascular lesion and its dramatic recovery after donepezil administration were reported. A 68-year-old man had suffered for a month from delirium of mixed type caused by the right basal forebrain vascular lesion after surgery for craniopharyngioma. Magnetic resonance imaging (MRI) showed hemorrhagic infarcts in the head of the right caudate nucleus and the right basal forebrain of the medial septal nucleus, diagonal band of Broca and nucleus basalis of Meynert. He had been treated with anti-psychotics, anti-depressants and hypnotics, which resulted in little improvement. Donepezil administration dramatically improved his intractable delirium at the 19th post-donepezil administration day, but this was followed by amnestic symptoms. Clinical correlates of delirium with the basal forebrain lesion and efficacy of donepezil support the hypocholinergic theory of delirium.
Katsuji Kobayashi; Masato Higashima; Kouhei Mutou; Tomokazu Kidani; Osamu Tachibana; Jonkoh Yamashita; Yoshifumi Koshino
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Progress in neuro-psychopharmacology & biological psychiatry     Volume:  28     ISSN:  0278-5846     ISO Abbreviation:  Prog. Neuropsychopharmacol. Biol. Psychiatry     Publication Date:  2004 Nov 
Date Detail:
Created Date:  2004-12-21     Completed Date:  2005-02-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8211617     Medline TA:  Prog Neuropsychopharmacol Biol Psychiatry     Country:  England    
Other Details:
Languages:  eng     Pagination:  1189-94     Citation Subset:  IM    
Department of Psychiatry and Neurobiology, Kanazawa University Graduate School of Medical Sciences, 13-1, Takara-machi, Kanazawa, Ishikawa-ken, 920-8641, Japan.
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MeSH Terms
Basal Ganglia Cerebrovascular Disease / drug therapy*,  pathology
Basal Nucleus of Meynert / pathology
Craniopharyngioma / complications,  surgery
Delirium / drug therapy*,  etiology*
Indans / therapeutic use*
Magnetic Resonance Imaging
Nootropic Agents / therapeutic use*
Piperidines / therapeutic use*
Pituitary Neoplasms / complications,  surgery
Postoperative Complications / drug therapy,  psychology
Prosencephalon / pathology*
Sleep Disorders / drug therapy,  etiology
Vision Disorders / complications
Reg. No./Substance:
0/Indans; 0/Nootropic Agents; 0/Piperidines; 120011-70-3/donepezil

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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