Document Detail

Severe cystitis associated with tiaprofenic acid.
MedLine Citation:
PMID:  9126086     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To review the UK spontaneous reports of urinary disorders associated with tiaprofenic acid and other non-steroidal anti-inflammatory drugs (NSAIDs) and put them into context of the usage of these preparations in the UK. METHODS: Suspected adverse drug reaction (ADR) reports of urinary disorders associated with tiaprofenic acid and other NSAIDs received by the UKs spontaneous ADR reporting scheme were analysed. RESULTS: Between 1982, when tiaprofenic acid was introduced in the UK, and August 1994, 69 cases of cystitis were reported, with a further 32 reports describing related urinary symptoms including frequency, dysuria and haematuria. Only eight cases of cystitis were reported for all other NSAIDs. The duration of treatment with tiaprofenic acid before the onset of urinary symptoms varied markedly (range 2 days to > 3 years). In patients in whom a drug-induced cause was suspected and the drug was stopped promptly, recovery usually occurred within weeks. However, many patients continued on long-term treatment with tiaprofenic acid and underwent extensive investigations to determine the cause of their urinary symptoms. On cystoscopy and biopsy, the findings were similar to interstitial cystitis. Most patients with chronic cystitis recovered after withdrawal of tiaprofenic acid, but some patients had surgery before the drug was stopped. CONCLUSION: Tiaprofenic acid can cause severe cystitis. These reports highlight the importance of taking a full drug history in patients with unexplained chronic cystitis. Tiaprofenic acid should be stopped immediately in all patients developing urinary symptoms.
M L Crawford; P C Waller; S M Wood
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  British journal of urology     Volume:  79     ISSN:  0007-1331     ISO Abbreviation:  Br J Urol     Publication Date:  1997 Apr 
Date Detail:
Created Date:  1997-05-16     Completed Date:  1997-05-16     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  15740090R     Medline TA:  Br J Urol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  578-84     Citation Subset:  IM    
Medicines Control Agency, London, UK.
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MeSH Terms
Adverse Drug Reaction Reporting Systems
Aged, 80 and over
Anti-Inflammatory Agents, Non-Steroidal / adverse effects*
Chronic Disease
Cystitis / chemically induced*
Cystitis, Interstitial / chemically induced
Middle Aged
Propionic Acids / adverse effects*
Reg. No./Substance:
0/Anti-Inflammatory Agents, Non-Steroidal; 0/Propionic Acids; 33005-95-7/tiaprofenic acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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