Document Detail

Severe cognitive and motor coordination deficits in tenascin-R-deficient mice.
MedLine Citation:
PMID:  12882316     Owner:  NLM     Status:  MEDLINE    
The extracellular matrix molecule tenascin-R (TN-R), predominantly expressed in the central nervous system, has been implied in a variety of functions, e.g. during myelination, cerebellar neurite fasciculation and hippocampal long-term potentiation. In this study, we investigated in detail the impact of TN-R deficiency on the living animal by analyzing the behavior of TN-R-deficient mice. The general state, gross sensory functions, reflexes and motoric capabilities appeared normal. In contrast, motor coordination on the rota-rod was compromised in these mice, indicating a deficit in cerebellar functions. In the open field and the hole board, the mutants interact differently with their environment, probably due to differences in their exploratory behavior. TN-R-deficient mice were able to learn a reference memory task in the Morris water maze. In contrast to wild-type mice, the mutants displayed an alternative strategy; swimming around the pool using a stereotypical circling pattern, crossing all possible platform positions after relocation of the escape platform (reversal). These results, confirmed by relocating the platform in the center of the pool, suggest that TN-R-deficient mice may be impaired in constructing a goal-independent representation of space. In addition, a two-way active avoidance test (shuttle box) revealed a severe deficit in associative learning in TN-R-deficient mice. Our results support important functions of TN-R in vivo in the central nervous system, in particular in the cerebellum and the hippocampus.
M Montag-Sallaz; D Montag
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Genes, brain, and behavior     Volume:  2     ISSN:  1601-1848     ISO Abbreviation:  Genes Brain Behav.     Publication Date:  2003 Feb 
Date Detail:
Created Date:  2003-07-28     Completed Date:  2003-08-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  101129617     Medline TA:  Genes Brain Behav     Country:  England    
Other Details:
Languages:  eng     Pagination:  20-31     Citation Subset:  IM    
Neurogenetics Research Group, Leibniz Institute for Neurobiology, Brenneckestr., Magdeburg, Germany.
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MeSH Terms
Avoidance Learning / physiology
Cell Adhesion Molecules / deficiency,  genetics,  physiology
Cognition / physiology*
Exploratory Behavior / physiology
Hand Strength / physiology
Maze Learning / physiology
Mice, Knockout
Motor Activity / genetics*
Psychomotor Performance / physiology*
Tenascin / deficiency,  genetics,  physiology*
Reg. No./Substance:
0/Cell Adhesion Molecules; 0/Tenascin; 147604-77-1/tenascin R

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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