| Severe coagulopathy caused by rifampicin in patients with primary sclerosing cholangitis and refractory pruritus. | |
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MedLine Citation:
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PMID: 22122359 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Aims: We report two cases of patients with end stage primary sclerosing cholangitis and intractable pruritus. Rifampicin was used as a second line agent for symptom control. Both patients developed severe coagulopathy with prothrombin time prolongation. Methods: Serum liver function tests were performed to rule out toxic hepatitis secondary to rifampicin as a cause for the coagulopathy. The patients' coagulation profile was further characterized by clotting factors quantification. Results: Low levels of the vitamin K dependent factors (II, VII, IX, X) were detected. The coagulopathy resolved fully with administration of parenteral vitamin K, suggesting that rifampicin induced hypoprothrombinaemia is mediated by vitamin K deficiency. Conclusion: To the best of our knowledge, this adverse effect has never before been described with the use of rifampicin in primary sclerosing cholangitis. We review the pathophysiology and discuss the need for vitamin K replacement in severely cholestatic patients prior to treatment with rifampicin. |
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Authors:
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Fotios Sampaziotis; William Jh Griffiths |
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Publication Detail:
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Type: LETTER Date: 2011-11-29 |
Journal Detail:
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Title: British journal of clinical pharmacology Volume: - ISSN: 1365-2125 ISO Abbreviation: - Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-11-29 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7503323 Medline TA: Br J Clin Pharmacol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© 2011 The Authors. British Journal of Clinical Pharmacology © 2011 The British Pharmacological Society. |
Affiliation:
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Department of Hepatology, Cambridge University Hospitals NHS Foundation Trust, Addenbrookes Hospital, Cambridge CB2 0QQ, United Kingdom (Sampaziotis F and Griffiths WJH). |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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