Document Detail

Severe coagulation abnormalities in Reye syndrome.
MedLine Citation:
PMID:  894409     Owner:  NLM     Status:  MEDLINE    
Coagulation studies were performed on 13 children with clinical diagnoses of Reye syndrome. Four had abnormalities so severe that transfusion of coagulation factors and platelets were required prior to percutaneous liver biopsy. In one of these, abnormalities frequently found in association with acute hepatic failure were present. Disseminated intravascular coagulation was noted in two, while in the fourth child laboratory data were most consistent with that process. Although the coagulation defect associated with Reye syndrome is most often due to decreased production of all coagulation factors except VIII, these patients demonstrate that consumption can also occur. The severity of the coagulopathies found indicates that bleeding can become a major complication in the diagnosis and management of Reye syndrome.
C Pegelow; R Goldberg; S Turkel; D Powars
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The Journal of pediatrics     Volume:  91     ISSN:  0022-3476     ISO Abbreviation:  J. Pediatr.     Publication Date:  1977 Sep 
Date Detail:
Created Date:  1977-10-20     Completed Date:  1977-10-20     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0375410     Medline TA:  J Pediatr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  413-6     Citation Subset:  AIM; IM    
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MeSH Terms
Blood Coagulation Disorders / etiology*
Blood Coagulation Tests
Disseminated Intravascular Coagulation / etiology
Hemorrhage / etiology
Reye Syndrome / blood,  complications*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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