| Severe chronic neutropenia--a case report. | |
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MedLine Citation:
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PMID: 16295383 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Severe chronic neutropenia (SCN) is a very rare disease with around 650 people worldwide known to have the condition. SCN is a serous condition with a considerable morbidity and mortality if not treated. We hereby report a case of SCN which had repeated admissions to the hospital with severe neutropenia and high grade fever. We also review the literature elucidating some of the mechanisms and consequences of SCN ( e.g: the neutrophil elastase gene mutations and the risk of progression to myelodysplasia and acute leukemia) and the role of granulocyte-colony stimulating factor. |
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Authors:
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Sunil Bahl; Thomas Vurgese; Ali Parappil |
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Publication Detail:
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Type: Case Reports; Journal Article; Review |
Journal Detail:
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Title: Indian journal of pathology & microbiology Volume: 47 ISSN: 0377-4929 ISO Abbreviation: Indian J Pathol Microbiol Publication Date: 2004 Oct |
Date Detail:
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Created Date: 2005-11-18 Completed Date: 2005-12-23 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7605904 Medline TA: Indian J Pathol Microbiol Country: India |
Other Details:
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Languages: eng Pagination: 523-5 Citation Subset: IM |
Affiliation:
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Department of Pathology, Al-Jahra Hospital, Jahra, Kuwait. suruchi_kt@hotmail.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Chronic Disease Granulocyte Colony Stimulating Factor, Recombinant / therapeutic use Humans Leukocyte Elastase / genetics Male Mutation Neutropenia / blood, diagnosis, drug therapy, etiology* |
| Chemical | |
Reg. No./Substance:
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0/Granulocyte Colony Stimulating Factor, Recombinant; EC 3.4.21.37/Leukocyte Elastase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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