Document Detail


Severe chronic neutropenia--a case report.
MedLine Citation:
PMID:  16295383     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Severe chronic neutropenia (SCN) is a very rare disease with around 650 people worldwide known to have the condition. SCN is a serous condition with a considerable morbidity and mortality if not treated. We hereby report a case of SCN which had repeated admissions to the hospital with severe neutropenia and high grade fever. We also review the literature elucidating some of the mechanisms and consequences of SCN ( e.g: the neutrophil elastase gene mutations and the risk of progression to myelodysplasia and acute leukemia) and the role of granulocyte-colony stimulating factor.
Authors:
Sunil Bahl; Thomas Vurgese; Ali Parappil
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Indian journal of pathology & microbiology     Volume:  47     ISSN:  0377-4929     ISO Abbreviation:  Indian J Pathol Microbiol     Publication Date:  2004 Oct 
Date Detail:
Created Date:  2005-11-18     Completed Date:  2005-12-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7605904     Medline TA:  Indian J Pathol Microbiol     Country:  India    
Other Details:
Languages:  eng     Pagination:  523-5     Citation Subset:  IM    
Affiliation:
Department of Pathology, Al-Jahra Hospital, Jahra, Kuwait. suruchi_kt@hotmail.com
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Chronic Disease
Granulocyte Colony Stimulating Factor, Recombinant / therapeutic use
Humans
Leukocyte Elastase / genetics
Male
Mutation
Neutropenia / blood,  diagnosis,  drug therapy,  etiology*
Chemical
Reg. No./Substance:
0/Granulocyte Colony Stimulating Factor, Recombinant; EC 3.4.21.37/Leukocyte Elastase

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