| Severe cerebral white matter hyperintensities predict severe cognitive decline in patients with cerebrovascular disease history. | |
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MedLine Citation:
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PMID: 19390070 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND AND PURPOSE: Cerebral white matter hyperintensities (WMHs) are believed to be the consequence of small vessel disease, and it is uncertain whether their extent predicts the risk of dementia in patients with vascular disease history. Method- Brain MRI was performed in 226 participants of the PROGRESS study. WMH severity was assessed using a visual rating scale. During follow-up, patients were classified for incident severe cognitive deterioration (including dementia) using standard criteria. RESULTS: Over 4-year follow-up, the incidence of severe cognitive deterioration ranged from 1.1 to 9.1 per 100 person-years in patients with respectively no or severe WMHs at baseline. In multivariable analysis, incident severe cognitive deterioration was associated with baseline severe WMHs (odds ratio=7.7, P<0.005). CONCLUSIONS: Higher WMH load is a strong predictor of dementia and cognitive decline in patients with cerebrovascular disease history. |
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Authors:
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Carole Dufouil; Ophélia Godin; John Chalmers; Oghuzan Coskun; Stephen MacMahon; Nathalie Tzourio-Mazoyer; Marie-Germaine Bousser; Craig Anderson; Bernard Mazoyer; Christophe Tzourio; |
Publication Detail:
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Type: Letter; Randomized Controlled Trial; Research Support, Non-U.S. Gov't Date: 2009-04-23 |
Journal Detail:
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Title: Stroke; a journal of cerebral circulation Volume: 40 ISSN: 1524-4628 ISO Abbreviation: Stroke Publication Date: 2009 Jun |
Date Detail:
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Created Date: 2009-05-25 Completed Date: 2009-06-12 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0235266 Medline TA: Stroke Country: United States |
Other Details:
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Languages: eng Pagination: 2219-21 Citation Subset: IM |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Angiotensin-Converting Enzyme Inhibitors / therapeutic use Brain / pathology* Cerebrovascular Disorders / pathology*, psychology* Cognition Disorders / pathology*, psychology* Dementia / pathology, psychology Disease Progression Female Follow-Up Studies Humans Ischemic Attack, Transient / pathology, psychology Magnetic Resonance Imaging Male Middle Aged Neuropsychological Tests Perindopril / therapeutic use Predictive Value of Tests Recurrence Stroke / pathology, psychology |
| Chemical | |
Reg. No./Substance:
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0/Angiotensin-Converting Enzyme Inhibitors; 82834-16-0/Perindopril |
| Investigator | |
Investigator/Affiliation:
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H Brugeilles / ; P Lejeune / ; C Moreau / ; A Pasco / ; S Iglesias / ; F Viader / ; J M Constant / ; P Courtheoux / ; A Jaillard / ; J M Besson / ; M Hommel / ; S Grand / ; J F Lebas / ; C Lucas / ; D Leys / ; X Leclerc / ; J P Pruvost / ; V Neuville / ; T Rosolacci / ; A Ameri / ; F Chedru / ; P Bérou / ; B Guillon / ; G Hinzelin / ; Feve / ; E Auffray / ; H Desal / ; De Kersaint-Gilly / ; V Biousse / ; K Berthet / ; K Vahedi / ; M G Bousser / ; V Bousson / ; C Levy / ; L Brunereau / ; J Tubiana / ; S Alamovitch / ; E Roullet / ; T De Broucker / ; N Gauthier / ; Stroh-Marcy / ; P Dobbelaere / ; M T Iba-Zizen / ; S Cabanis / |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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