Document Detail

Severe cerebral white matter hyperintensities predict severe cognitive decline in patients with cerebrovascular disease history.
MedLine Citation:
PMID:  19390070     Owner:  NLM     Status:  MEDLINE    
BACKGROUND AND PURPOSE: Cerebral white matter hyperintensities (WMHs) are believed to be the consequence of small vessel disease, and it is uncertain whether their extent predicts the risk of dementia in patients with vascular disease history. Method- Brain MRI was performed in 226 participants of the PROGRESS study. WMH severity was assessed using a visual rating scale. During follow-up, patients were classified for incident severe cognitive deterioration (including dementia) using standard criteria. RESULTS: Over 4-year follow-up, the incidence of severe cognitive deterioration ranged from 1.1 to 9.1 per 100 person-years in patients with respectively no or severe WMHs at baseline. In multivariable analysis, incident severe cognitive deterioration was associated with baseline severe WMHs (odds ratio=7.7, P<0.005). CONCLUSIONS: Higher WMH load is a strong predictor of dementia and cognitive decline in patients with cerebrovascular disease history.
Carole Dufouil; Ophélia Godin; John Chalmers; Oghuzan Coskun; Stephen MacMahon; Nathalie Tzourio-Mazoyer; Marie-Germaine Bousser; Craig Anderson; Bernard Mazoyer; Christophe Tzourio;
Publication Detail:
Type:  Letter; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2009-04-23
Journal Detail:
Title:  Stroke; a journal of cerebral circulation     Volume:  40     ISSN:  1524-4628     ISO Abbreviation:  Stroke     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-05-25     Completed Date:  2009-06-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0235266     Medline TA:  Stroke     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2219-21     Citation Subset:  IM    
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MeSH Terms
Angiotensin-Converting Enzyme Inhibitors / therapeutic use
Brain / pathology*
Cerebrovascular Disorders / pathology*,  psychology*
Cognition Disorders / pathology*,  psychology*
Dementia / pathology,  psychology
Disease Progression
Follow-Up Studies
Ischemic Attack, Transient / pathology,  psychology
Magnetic Resonance Imaging
Middle Aged
Neuropsychological Tests
Perindopril / therapeutic use
Predictive Value of Tests
Stroke / pathology,  psychology
Reg. No./Substance:
0/Angiotensin-Converting Enzyme Inhibitors; 82834-16-0/Perindopril
H Brugeilles / ; P Lejeune / ; C Moreau / ; A Pasco / ; S Iglesias / ; F Viader / ; J M Constant / ; P Courtheoux / ; A Jaillard / ; J M Besson / ; M Hommel / ; S Grand / ; J F Lebas / ; C Lucas / ; D Leys / ; X Leclerc / ; J P Pruvost / ; V Neuville / ; T Rosolacci / ; A Ameri / ; F Chedru / ; P Bérou / ; B Guillon / ; G Hinzelin / ; Feve / ; E Auffray / ; H Desal / ; De Kersaint-Gilly / ; V Biousse / ; K Berthet / ; K Vahedi / ; M G Bousser / ; V Bousson / ; C Levy / ; L Brunereau / ; J Tubiana / ; S Alamovitch / ; E Roullet / ; T De Broucker / ; N Gauthier / ; Stroh-Marcy / ; P Dobbelaere / ; M T Iba-Zizen / ; S Cabanis /

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