| Severe cerebral toxoplasma infection cannot be excluded by a normal CT scan. | |
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MedLine Citation:
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PMID: 19591247 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A fatal case is reported concerning a severely immunocompromised 50-year-old female renal transplant recipient who developed fever and confusion. Cerebral imaging with contrast-enhanced computed tomography (CT) scans showed no abnormalities while subsequently performed magnetic resonance imaging (MRI ) showed clear abnormalities in the basal ganglia. By that time serology and polymerase chain reaction had confirmed the diagnosis of cerebral toxoplasmosis. Because of the suboptimal sensitivity of these tests negative results should be handled with care. Once cerebral toxoplasmosis is suspected in at-risk patients, treatment should be started empirically pending the confirmation of the diagnosis. A normal cerebral CT scan does not preclude cerebral toxoplasmosis.In these situations MRI can give important additional information. |
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Authors:
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J J Weenink; A G Weenink; S E Geerlings; T van Gool; F J Bemelman |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: The Netherlands journal of medicine Volume: 67 ISSN: 1872-9061 ISO Abbreviation: Neth J Med Publication Date: 2009 Apr |
Date Detail:
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Created Date: 2009-07-10 Completed Date: 2009-12-03 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0356133 Medline TA: Neth J Med Country: Netherlands |
Other Details:
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Languages: eng Pagination: 150-2 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine, Renal Transplant Unit, Center for Infection and Immunity Amsterdam (CINIMA), Academic Medical Centre, Amsterdam, the Netherlands. jweenink@tsz.nl |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Brain / parasitology, radiography Diagnosis, Differential Fatal Outcome Female Ghana Humans Immunocompromised Host* Immunosuppressive Agents / administration & dosage Kidney Transplantation / immunology Magnetic Resonance Imaging Middle Aged Polymerase Chain Reaction Tomography, X-Ray Computed* Toxoplasma / isolation & purification Toxoplasmosis, Cerebral / diagnosis, radiography* |
| Chemical | |
Reg. No./Substance:
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0/Immunosuppressive Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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