Document Detail

Severe bullous skin lesions associated with Chikungunya virus infection in small infants.
MedLine Citation:
PMID:  19401826     Owner:  NLM     Status:  MEDLINE    
INTRODUCTION: The aim of this study was to describe a pediatric case series of Chikungunya infection associated with extensive bullous skin lesions, a severe and unknown form of the disease, during the 2005-2006 outbreak in La R?union Island. MATERIALS AND METHODS: Retrospective descriptive hospital-based study in children presenting blisters > or = 10% of total body surface area with laboratory-confirmed Chikungunya infection. RESULTS: Eight boys and five girls with a mean age of 3.4 months were included. Blistering began after an average of 2 days after onset of fever and affected 21.5% (10% to 35%) of the total body surface area. Reverse transcription-polymerase chain reaction of blister fluid (n = 5) was positive with a mean viral load sometimes higher than in concurrent serum. Histopathologic examination (n = 10) showed intraepidermal blisters. Hospitalization and repeated dressing changes under general anesthesia were required. No death occurred. On follow-up, long term repigmentation was excellent with sometimes cosmetic sequelae. CONCLUSION: Chikungunya should be included in the differential diagnosis of febrile blistering dermatoses in small infants in epidemic areas.
St?phanie Robin; Duksha Ramful; Julie Zettor; L?on Benhamou; Marie-Christine Jaffar-Bandjee; Jean-Pierre Rivi?re; Jacques Marichy; Khaled Ezzedine; Jean-Luc Alessandri
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Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2009-04-29
Journal Detail:
Title:  European journal of pediatrics     Volume:  169     ISSN:  1432-1076     ISO Abbreviation:  Eur. J. Pediatr.     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2009-11-12     Completed Date:  2010-02-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7603873     Medline TA:  Eur J Pediatr     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  67-72     Citation Subset:  IM    
Service de P?diatrie, Centre Hospitalier F?lix Guyon, CHR R?union, All?e des Topazes, 97405 Saint-Denis, La R?union, France.
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MeSH Terms
Alphavirus Infections / diagnosis,  drug therapy,  virology*
Antibodies, Viral / analysis
Chikungunya virus / genetics,  immunology,  isolation & purification*
DNA, Viral / analysis
Diagnosis, Differential
Enzyme-Linked Immunosorbent Assay
Follow-Up Studies
Immunoglobulins, Intravenous / therapeutic use
Immunologic Factors / administration & dosage
Infant, Newborn
Polymerase Chain Reaction
Retrospective Studies
Skin / pathology,  virology
Skin Diseases, Vesiculobullous / diagnosis,  drug therapy,  virology*
Treatment Outcome
Viral Load
Reg. No./Substance:
0/Antibodies, Viral; 0/DNA, Viral; 0/Immunoglobulins, Intravenous; 0/Immunologic Factors

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