| Severe aseptic leucoencephalopathy as immune reconstitution inflammatory syndrome in Caucasian and African patients. | |
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MedLine Citation:
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PMID: 19424053 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Immune reconstitution inflammatory syndrome (IRIS) after HAART may become manifest in form of aseptic severe leucoencephalopathy. All HIV-1-positive patients in this case series had widespread laboratory tests and follow-up MRI in order to investigate the course and the underlying pathophysiology of IRIS-associated leucoencephalopathy. All patients were treated with corticosteroids, in spite of additional immunosuppression. Three patients were successfully treated with corticosteroids and survived up to now, one died. A neuropathological examination was performed showing massive aseptic intraparenchymal and perivascular invasion of cytotoxic CD8 cells. It is assumed that IRIS-associated leucoencephalopathy is based on other preconditions in Africans and Caucasians. |
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Authors:
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Adrian Ringelstein; Christian Oelschlaeger; Andreas Saleh; Christian Mathys; Rainer Dziewas; Thomas Niederstadt; Doris Reichelt; Martin Hasselblatt; Ingo W Husstedt; Gabriele Arendt |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: AIDS (London, England) Volume: 23 ISSN: 1473-5571 ISO Abbreviation: AIDS Publication Date: 2009 Jul |
Date Detail:
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Created Date: 2009-06-30 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8710219 Medline TA: AIDS Country: England |
Other Details:
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Languages: eng Pagination: 1435-7 Citation Subset: IM; X |
Affiliation:
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Department of Neurology, Heinrich Heine University, Duesseldorf, Germany. a.ringelstein@gmx.de |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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