Document Detail

Severe amiodarone-induced hypothyroidism in an infant.
MedLine Citation:
PMID:  20453707     Owner:  NLM     Status:  In-Process    
OBJECTIVE: To report a case of postnatal, postoperative amiodarone-induced hypothyroidism in an infant with a congenital heart defect.
DESIGN: Case report and literature review.
SETTING: Pediatric intensive care unit at a freestanding tertiary care children's hospital.
PATIENT: At 7 wks of age, a female infant with a congenital heart defect was confirmed to have profound hypothyroidism after amiodarone administration for a postoperative cardiac arrhythmia.
INTERVENTIONS: Levothyroxine treatment.
MEASUREMENTS AND MAIN RESULTS: Thyroid function tests were regularly performed to guide levothyroxine dosing. Thyroid hormone replacement was discontinued after the infant had been off amiodarone for 6 mos.
CONCLUSIONS: Given the potential adverse developmental consequences associated with hypothyroidism during infancy and early childhood, thyroid function tests should be carefully monitored in any infant treated with amiodarone.
Karen Trudel; Shubhayan Sanatani; Constadina Panagiotopoulos
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies     Volume:  12     ISSN:  1529-7535     ISO Abbreviation:  Pediatr Crit Care Med     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-01-06     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100954653     Medline TA:  Pediatr Crit Care Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  e43-5     Citation Subset:  IM    
Division of Cardiology, University of British Columbia and British Columbia Children's Hospital, Vancouver, BC, Canada.
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