Document Detail


Severe abdominal infections in neutropenic patients.
MedLine Citation:
PMID:  11577807     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Abdominal infections are an important cause of morbidity and mortality in neutropenic patients. We present a retrospective series of 16 patients, mostly with acute leukemia, who developed severe abdominal infections during chemotherapy-induced neutropenia between 1991 and 1997. The frequency among patients with acute leukemia was 2.35% (13 of 553). Thirteen patients presented with enterocolitis and 3 patients presented with cholecystitis. Eight patients died. Bacteremia was present in 6 patients, 4 patients suffered from proven or strongly suspected fungal infections, and 1 patient suffered from cytomegalovirus infection. Early surgical management was required in a patient with intestinal obstruction, whereas other patients could be managed conservatively. Two patients with acute cholecystitis were treated with antibiotics until the end of neutropenia and then were resected. Severe abdominal injections in neutropenic patients, which are often fatal, were caused by nonbacterial microorganisms in one-fourth of the cases and could be managed conservatively in most instances.
Authors:
M Gorschlüter; A Glasmacher; C Hahn; C Leutner; G Marklein; J Remig; I G Schmidt-Wolf; T Sauerbruch
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cancer investigation     Volume:  19     ISSN:  0735-7907     ISO Abbreviation:  Cancer Invest.     Publication Date:  2001  
Date Detail:
Created Date:  2001-10-01     Completed Date:  2001-10-11     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8307154     Medline TA:  Cancer Invest     Country:  United States    
Other Details:
Languages:  eng     Pagination:  669-77     Citation Subset:  IM    
Affiliation:
Department of Internal Medicine I, University of Bonn, Germany. gorschlueter@uni-bonn.de
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MeSH Terms
Descriptor/Qualifier:
Abdomen / microbiology,  pathology
Adult
Aged
Bacteremia / etiology*,  pathology
Cholecystitis / etiology*,  pathology
Cytomegalovirus Infections / etiology*,  pathology
Fatal Outcome
Female
Fungemia / etiology*,  pathology
Humans
Male
Middle Aged
Neoplasms / complications,  drug therapy
Neutropenia / complications*
Retrospective Studies

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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